Selective estrogen receptor modulators protect hippocampal neurons from kainic acid excitotoxicity: differences with the effect of estradiol

Journal of Neurobiology
Iratxe CirizaLuis M Garcia-Segura

Abstract

Neuroprotective effects of estradiol are well characterized in animal experimental models. However, in humans, the outcome of estrogen treatment for cognitive function and neurological diseases is very controversial. Selective estrogen receptor modulators (SERMs) may represent an alternative to estrogen for the treatment or the prevention of neurodegenerative disorders. SERMs interact with the estrogen receptors and have tissue-specific effects distinct from those of estradiol, acting as estrogen agonists in some tissues and as antagonists in others. In this study we have assessed the effect of tamoxifen, raloxifene, lasofoxifene (CP-336,156), bazedoxifene (TSE-424), and 17beta-estradiol on the hippocampus of adult ovariectomized rats, after the administration of the excitotoxin kainic acid. Administration of kainic acid induced the expression of vimentin in reactive astroglia and a significant neuronal loss in the hilus. SERMs did not affect vimentin immunoreactivity in the hilus, while 17beta-estradiol significantly reduced the surface density of vimentin immunoreactive profiles. Estradiol, tamoxifen (0.4-2 mg/kg), raloxifene (0.4-2 mg/kg), and bazedoxifene (2 mg/kg) prevented neuronal loss in the hilus after the administrati...Continue Reading

References

Jan 20, 1992·Neuroscience Letters·B Gomez-Mancilla, P J Bédard
Dec 1, 1991·Journal of Neurobiology·G A Mathews, A P Arnold
Aug 19, 1991·Brain Research. Developmental Brain Research·L D Pozzo Miller, A Aoki
May 1, 1989·Journal of Molecular Endocrinology·A E WakelingS W Peters
Jan 1, 1987·Journal of Steroid Biochemistry·L M Garcia-SeguraF Naftolin
May 1, 1988·Biology of Reproduction·V E QuarmbyK S Korach
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jul 5, 1996·Neuroscience Letters·C A SingerD M Dorsa
Oct 28, 1996·Archives of Internal Medicine·A Paganini-Hill, V W Henderson
Jan 7, 1998·Trends in Neurosciences·J L RidetF H Gage
Mar 13, 1998·JAMA : the Journal of the American Medical Association·K YaffeD Grady
Nov 6, 1998·Neuroreport·I AzcoitiaL M Garcia-Segura
Nov 11, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D B DubalP M Wise
Jan 1, 1999·Menopause : the Journal of the North American Menopause Society·J NilsenF Naftolin
Mar 17, 1999·The Journal of Endocrinology·M Christian, G Gillies
Apr 30, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J García-EstradaL M Garcia-Segura
May 5, 1999·Neurology·R Saunders-PullmanS Bressman
Dec 11, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P AmmannR Rizzoli
Jan 15, 2000·Advances in Experimental Medicine and Biology·M Nieto-Sampedro
May 19, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P S Green, J W Simpkins
Jun 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H SawadaS Shimohama
Jun 22, 2000·Journal of Neurocytology·I AzcoitiaL M Garcia-Segura
Jun 28, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M CyrT Di Paolo
Oct 21, 2000·Progress in Neurobiology·L M Garcia-SeguraL L DonCarlos

❮ Previous
Next ❯

Citations

Jan 2, 2010·Cellular and Molecular Neurobiology·Ofir PicazoLuis M Garcia-Segura
Jul 23, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul NewhouseJulie Dumas
Dec 18, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Elena Huerta-RamosJudith Usall
Dec 14, 2011·Neural Plasticity·Ignacio González-BurgosLuis Miguel Garcia-Segura
Jan 22, 2014·Molecular and Cellular Endocrinology·Estefania Acaz-FonsecaLuis M Garcia-Segura
May 28, 2014·Neuroscience Letters·María Castelló-RuizEnrique Alborch
Feb 9, 2010·Journal of Women's Health·Mark A EspelandSusan M Resnick
Apr 11, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Iñigo AzcoitiaLuis M Garcia-Segura
Jul 5, 2011·Expert Review of Neurotherapeutics·Adrianna Mendrek, Emmanuel Stip
Aug 19, 2006·Expert Opinion on Investigational Drugs·Luigi GennariRanuccio Nuti
Feb 13, 2016·Frontiers in Endocrinology·Andrea Rodrigues VasconcelosElisa Mitiko Kawamoto
Mar 10, 2012·Hormones and Behavior·María Angeles ArevaloLuis M Garcia-Segura
Mar 8, 2011·Hormones and Behavior·Natalia LagunasLuis M Garcia-Segura
Dec 15, 2015·Neuroscience and Biobehavioral Reviews·Roberto C MelcangiLuis M Garcia-Segura
Oct 13, 2009·Biochimica Et Biophysica Acta·María-Angeles ArevaloLuis M Garcia-Segura
May 19, 2009·Psychoneuroendocrinology·Lydia L DonCarlosLuis M Garcia-Segura
May 16, 2008·Neuroscience·M C McCordP E Schauwecker
Jul 21, 2007·Psychoneuroendocrinology·Muriel DarnaudéryStefania Maccari
Jul 31, 2007·Pharmacology & Therapeutics·Michael SchumacherAlejandro F De Nicola
May 14, 2011·Journal of Neuroendocrinology·M A ArevaloL M Garcia-Segura
Dec 15, 2010·The European Journal of Neuroscience·Iñigo AzcoitiaLuis M Garcia-Segura
Jun 19, 2010·CNS Neuroscience & Therapeutics·Maria Gabriela SánchezThérèse Di Paolo
May 9, 2006·Neurotoxicology·Chellu S ChettyChalla Suresh
Dec 14, 2005·Neuroscience·R C Melcangi, G C Panzica
Jun 2, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Helen M Bramlett
Dec 17, 2009·Clinical Science·Hilary V O CarswellTracy D Farr
Jul 23, 2008·Experimental Neurology·Monica M SiegenthalerHans S Keirstead
Nov 27, 2014·Nature Reviews. Neuroscience·Maria-Angeles ArevaloLuis M Garcia-Segura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.