Selective excitatory actions of DNQX and CNQX in rat thalamic neurons.

Journal of Neurophysiology
Sang-Hun LeeCharles L Cox

Abstract

The thalamic reticular nucleus (TRN) consists of GABA-containing neurons that form reciprocal synaptic connections with thalamic relay nuclei. Excitatory synaptic innervation of TRN neurons arises from glutamatergic afferents from thalamocortical relay neurons and deep layer corticothalamic neurons, and they produce excitation via both N-methyl-D-aspartate (NMDA) and non-NMDA receptors. Quinoxaline derivatives [e.g., 6,7-dinitroquinoxaline-2,3-dione (DNQX), 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX)] have routinely been used as non-NMDA receptor antagonists over the last two decades. In this study, we examined whether quinoxaline derivatives alter the intrinsic properties of thalamic neurons in light of recent findings indicating that these compounds can alter neuronal excitability in hippocampal and cerebellar neurons via transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs). Whole cell recordings were obtained from TRN and ventrobasal (VB) thalamic relay neurons in vitro. DNQX and CNQX produced a consistent depolarization in all TRN neurons tested. The depolarization persisted in tetrodotoxin and low Ca²+/high Mg²+ conditions, suggesting a postsynaptic site of action. In contrast, DNQX and CNQX produced little or n...Continue Reading

References

Aug 1, 1975·The Journal of Comparative Neurology·E G Jones
Aug 3, 1990·Science·K KeinänenP H Seeburg
Sep 1, 1996·Journal of Neurophysiology·S M Sherman, R W Guillery
Aug 11, 1998·Nature Genetics·V A LettsW N Frankel
Mar 29, 2000·FEBS Letters·N KlugbauerF Hofmann
Nov 4, 2000·The American Journal of Psychiatry·H M IbrahimJ H Meador-Woodruff
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·P GolshaniE G Jones
Jun 8, 2002·Annual Review of Neuroscience·Roberto Malinow, Robert C Malenka
Oct 9, 2002·Neuropharmacology·G Maccaferri, R Dingledine
Oct 24, 2002·Trends in Neurosciences·Insuk Song, Richard L Huganir
Mar 11, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Edward G Jones
May 29, 2003·The Journal of Cell Biology·Susumu TomitaDavid S Bredt
Jan 22, 2004·Nature Reviews. Neuroscience·Gina G Turrigiano, Sacha B Nelson
Apr 29, 2005·Current Drug Targets. CNS and Neurological Disorders·Thomas Weiser
Sep 21, 2005·Neuroscience Research·Masahiro FukayaMasahiko Watanabe
Mar 4, 2006·Science·Roger A NicollDavid S Bredt
Mar 3, 2007·Neuron·Edward B Ziff
Apr 28, 2007·The Journal of Physiology·Sang-Hun LeeCharles L Cox
May 4, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akihiko S KatoDavid S Bredt
Jun 3, 2008·Trends in Pharmacological Sciences·Aaron D Milstein, Roger A Nicoll
Oct 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karen Menuz, Roger A Nicoll

❮ Previous
Next ❯

Citations

Mar 8, 2011·The European Journal of Neuroscience·Juan M AlfaroJavier S Burgos
Aug 25, 2015·Frontiers in Cellular Neuroscience·Jessica AramaJasmina N Jovanovic
Oct 14, 2011·Current Opinion in Neurobiology·Christoph Straub, Susumu Tomita
Sep 1, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Oksana SirenkoCassiano Carromeu
Aug 14, 2020·Journal of Neurophysiology·Irina N Beloozerova, Vladimir Marlinski
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·Ignacio Martínez-GarcíaFernando Peña-Ortega

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.