Selective expression of a subset of measles virus receptor-competent CD46 isoforms in human brain

Virology
C J BuchholzR Cattaneo

Abstract

The human cell surface protein CD46 is the main measles virus (MV) receptor. We analyzed the CD46 isoforms expressed in the brain of three patients who died with persistent MV infections and in an unaffected brain. Complete CD46 cDNAs were produced and found to code exclusively for CD46 isoforms with cytoplasmic tail 2. Selective expression of tail 2 isoforms was shown in a second control brain by Western blots with antibodies specific for each of the cytoplasmic tails. Binding of purified MV particles and virus-dependent cell fusion were tested after transient expression of brain-derived CD46 proteins in mouse cells. All the brain-derived proteins mediated MV binding and virus-dependent fusion. Isoforms containing both serine/threonine/proline (STP)-rich domains were more active in virus binding, whereas isoforms with only one STP domain were more efficient in mediating fusion.

Citations

Jan 11, 2000·Journal of Virology·A EvlashevB Horvat
Jun 26, 2001·Clinical and Experimental Immunology·C KemperJ P Atkinson
Jul 12, 2002·Molecular Reproduction and Development·Rebecca C RileyJohn P Atkinson
Jul 12, 2011·Immunobiology·Siobhan Ni Choileain, Anne L Astier
Jul 12, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Camilo Ayala-BretonKah-Whye Peng
Dec 27, 2018·Expert Review of Vaccines·Iana H HaralambievaGregory A Poland
Mar 1, 1997·Protein Science : a Publication of the Protein Society·C MumenthalerR Cattaneo
Aug 29, 1997·The Journal of Biological Chemistry·C J BuchholzR Cattaneo
Jul 20, 2002·Journal of Neuropathology and Experimental Neurology·Eric V ShustaWilliam M Pardridge
Apr 16, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Stephen McQuaid, Sara Louise Cosby
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G WangJ P Atkinson
Aug 8, 1998·Journal of Virology·B MrkicR Cattaneo

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