Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease.

Brain Research Bulletin
Simon P BrooksStephen B Dunnett

Abstract

People with early-stage Huntington's disease have been found to have a specific deficit in performing an extra-dimensional shift. To date no evidence of this deficit has been identified in transgenic or knock-in rodent models of the disease. The aim of the present paper then, was to test whether homozygous knock-in mice derived from the Hdh(CAG(150)) mouse line were impaired in any of five 2-choice discrimination tasks (simple, compound, compound reversal, intra-dimensional shift and extra-dimensional shift), and whether these mice were impaired at recalling these tasks on the following day. On the extra-dimensional shift task the Hdh(CAG(150)) homozygous mice required a greater number of trials to reach criteria than mice and the percentage of correct choices within the trials was also significantly reduced compared with the animals. For the recall tasks, a deficit for recalling the compound reversal test was found in the Hdh(CAG(150)) homozygous mice for both number of trials required to reach criteria and percentage of correct choices within the trials. Recall for the intra-dimensional shift task was also impaired in these animals when measured by the percentage of correct choices. Our results demonstrate a pronounced defici...Continue Reading

References

Oct 1, 1996·Brain : a Journal of Neurology·A D LawrenceT W Robbins
Nov 13, 2001·Brain Research Bulletin·A J MortonJ M Edwardson
Feb 21, 2002·Behavioural Brain Research·Giovanni ColaciccoHanno Würbel
Oct 23, 2003·Behavioral Neuroscience·Michael E RagozzinoCharlene Kiang
Feb 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roshan CoolsTrevor W Robbins
Aug 13, 2004·The European Journal of Neuroscience·Katy C ChenJoshua S Rodefer
Sep 3, 2004·The European Journal of Neuroscience·E Decamp, J S Schneider
Mar 8, 2005·Neuroscience·S J Tallaksen-GreeneR L Albin

❮ Previous
Next ❯

Citations

Sep 8, 2012·Molecular Neurobiology·Maciej FigielWlodzimierz J Krzyzosiak
Oct 19, 2011·Brain Research Bulletin·Simon P BrooksStephen B Dunnett
May 17, 2012·Brain Research Bulletin·Simon P Brooks, Stephen B Dunnett
Jul 23, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Martien J H KasCynthia M Bulik
Aug 17, 2016·Brain Pathology·Mar PuigdellívolEsther Pérez-Navarro
Jun 24, 2020·Behavioural Brain Research·Arianna NovatiHuu Phuc Nguyen
Oct 4, 2011·Brain Research Bulletin·Steven A FieldingStephen B Dunnett
Jun 9, 2012·Physiology & Behavior·Gregory B BissonetteElizabeth M Powell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.