Selective extracellular stimulation of individual neurons in ganglia.

Journal of Neural Engineering
Hui LuHillel J Chiel

Abstract

Selective control of individual neurons could clarify neural functions and aid disease treatments. To target specific neurons, it may be useful to focus on ganglionic neuron clusters, which are found in the peripheral nervous system in vertebrates. Because neuron cell bodies are found primarily near the surface of invertebrate ganglia, and often found near the surface of vertebrate ganglia, we developed a technique for controlling individual neurons extracellularly using the buccal ganglia of the marine mollusc Aplysia californica as a model system. We experimentally demonstrated that anodic currents can selectively activate an individual neuron and cathodic currents can selectively inhibit an individual neuron using this technique. To define spatial specificity, we studied the minimum currents required for stimulation, and to define temporal specificity, we controlled firing frequencies up to 45 Hz. To understand the mechanisms of spatial and temporal specificity, we created models using the NEURON software package. To broadly predict the spatial specificity of arbitrary neurons in any ganglion sharing similar geometry, we created a steady-state analytical model. A NEURON model based on cat spinal motor neurons showed response...Continue Reading

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Citations

Nov 11, 2010·Medical & Biological Engineering & Computing·Hui YePeter L Carlen
Jul 14, 2011·Journal of Neural Engineering·E J PetersonD J Tyler
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Mar 10, 2018·Journal of Neural Engineering·Zachariah J SperryTim M Bruns
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Jul 2, 2021·Scientific Reports·Hui Ye, Lauryn Barrett
Nov 27, 2021·Journal of Neural Engineering·Yu HuanHillel J Chiel

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