Selective Filopodia Adhesion Ensures Robust Cell Matching in the Drosophila Heart

Developmental Cell
Shaobo ZhangTimothy E Saunders

Abstract

The ability to form specific cell-cell connections within complex cellular environments is critical for multicellular organisms. However, the underlying mechanisms of cell matching that instruct these connections remain elusive. Here, we quantitatively explored the dynamics and regulation of cell matching processes utilizing Drosophila cardiogenesis. We found that cell matching is highly robust at boundaries between cardioblast (CB) subtypes, and filopodia of different CB subtypes have distinct binding affinities. Cdc42 is involved in regulating this selective filopodia binding adhesion and influences CB matching. Further, we identified adhesion molecules Fasciclin III (Fas3) and Ten-m, both of which also regulate synaptic targeting, as having complementary differential expression in CBs. Altering Fas3 expression changes differential filopodia adhesion and leads to CB mismatch. Furthermore, only when both Fas3 and Ten-m are lost is CB alignment severely impaired. Our results show that differential adhesion mediated by selective filopodia binding efficiently regulates precise and robust cell matching.

Citations

Jul 25, 2020·ELife·Alexandre CarayonJean-Louis Frendo
Aug 25, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tara M Finegan, Dan T Bergstralh
Feb 19, 2020·Development·Adrien Hallou, Thibaut Brunet
Feb 24, 2019·BMC Biology·Timothy E Saunders, Philip W Ingham
Dec 7, 2019·Development·Abhinava K MishraDenise J Montell
Jul 7, 2020·Annual Review of Cell and Developmental Biology·O Hamant, T E Saunders
Feb 16, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tiffany R KingSunita G Kramer
Jun 5, 2021·Biophysical Journal·Prabhat TiwariTimothy E Saunders
Jun 17, 2021·Seminars in Cell & Developmental Biology·Shaobo Zhang, Timothy Saunders
Jul 26, 2021·Current Opinion in Cell Biology·Rachna NarayananTimothy E Saunders

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