Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin.

Proceedings of the National Academy of Sciences of the United States of America
Daniel J ChristoffelR C Malenka

Abstract

The detailed mechanisms by which dopamine (DA) and serotonin (5-HT) act in the nucleus accumbens (NAc) to influence motivated behaviors in distinct ways remain largely unknown. Here, we examined whether DA and 5-HT selectively modulate excitatory synaptic transmission in NAc medium spiny neurons in an input-specific manner. DA reduced excitatory postsynaptic currents (EPSCs) generated by paraventricular thalamus (PVT) inputs but not by ventral hippocampus (vHip), basolateral amygdala (BLA), or medial prefrontal cortex (mPFC) inputs. In contrast, 5-HT reduced EPSCs generated by inputs from all areas except the mPFC. Release of endogenous DA and 5-HT by methamphetamine (METH) and (±)3,4-methylenedioxymethamphetamine (MDMA), respectively, recapitulated these input-specific synaptic effects. Optogenetic inhibition of PVT inputs enhanced cocaine-conditioned place preference, whereas mPFC input inhibition reduced the enhancement of sociability elicited by MDMA. These findings suggest that the distinct, input-specific filtering of excitatory inputs in the NAc by DA and 5-HT contribute to their discrete behavioral effects.

References

Jul 23, 1999·Annals of the New York Academy of Sciences·P O'DonnellA A Grace
Jun 9, 2000·Annual Review of Neuroscience·S M NicolaR C Malenka
Aug 7, 2002·Pharmacology & Therapeutics·Richard B Rothman, Michael H Baumann
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ko-Woon LeePaul Greengard
Aug 14, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Susan R Sesack, Anthony A Grace
Oct 22, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Demetrio Sierra-MercadoGregory J Quirk
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Herbert E CovingtonEric J Nestler
May 20, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian N MathurDavid M Lovinger
Dec 27, 2011·Biological Psychiatry·Garret D StuberAntonello Bonci
Apr 11, 2012·Journal of the American Chemical Society·Daria M ShcherbakovaVladislav V Verkhusha
Oct 4, 2012·Brain Research·Elizabeth E Steinberg, Patricia H Janak
Oct 9, 2012·Neuron·Nicolas X Tritsch, Bernardo L Sabatini
Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Brad A GrueterRobert C Malenka
Aug 15, 2013·Nature Reviews. Neuroscience·Scott J Russo, Eric J Nestler
Feb 11, 2014·Nature Methods·Nathan C KlapoetkeEdward S Boyden
May 23, 2014·Nature·Vincent PascoliChristian Lüscher
Aug 12, 2014·Nature Neuroscience·Andrew F MacAskillAdam G Carter
Aug 17, 2014·Learning & Memory·Jacqueline M BarkerL Judson Chandler
Sep 27, 2015·Neuroscience and Biobehavioral Reviews·Philip Kamilar-Britt, Gillinder Bedi
Jul 1, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eunee LeeMin Whan Jung
Jul 16, 2016·Cell·Boris D Heifets, Robert C Malenka
Jan 6, 2017·Nature Reviews. Neuroscience·Marisela Morales, Elyssa B Margolis
May 5, 2017·Neuron·Skyler L Jackman, Wade G Regehr
Nov 17, 2017·Nature Reviews. Neuroscience·Nora D VolkowRuben Baler
Jan 11, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wesley N Wayman, John J Woodward
Jun 21, 2018·Biological Psychiatry·Cindy BarrientosByung Kook Lim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.