Selective glucose sensing in complex media using a biomimetic receptor.

Chemical Science
Robert A TromansAnthony P Davis

Abstract

Glucose is a key biomedical analyte, especially relevant to the management of diabetes. Current methods for glucose determination rely on the enzyme glucose oxidase, requiring specialist instrumentation and suffering from redox-active interferents. In a new approach, a powerful and highly selective achiral glucose receptor is mixed with a sample, l-glucose is added, and the induced CD spectrum is measured. The CD signal results from competition between the enantiomers, and is used to determine the d-glucose content. The involvement of l-glucose doubles the signal range from the CD spectrometer and allows sensitivity to be adjusted over a wide dynamic range. It also negates medium effects, which must be equal for both enantiomers. The method has been demonstrated with human serum, pre-filtered to remove proteins, giving results which closely match the standard biochemical procedures, as well as a cell culture medium and a beer sample containing high (70 mM) and low (0.4 mM) glucose concentrations respectively.

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Citations

Nov 28, 2020·Journal of Molecular Graphics & Modelling·Rajesh KondabalaAmjad Ali
Mar 13, 2021·Diabetologia·Mark A JarosinskiMichael A Weiss
Apr 13, 2021·ACS Sensors·George T WilliamsJohn S Fossey
Oct 24, 2020·Biochemistry·M Fernando BravoAdam B Braunschweig
Nov 3, 2020·Molecular Metabolism·Thomas Hoeg-Jensen

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