Selective imaging of damaged bone structure (microcracks) using a targeting supramolecular Eu(III) complex as a lanthanide luminescent contrast agent

Journal of the American Chemical Society
Brian McMahonThorfinnur Gunnlaugsson

Abstract

The synthesis and photophysical evaluation of a new supramolecular lanthanide complex is described which was developed as a luminescent contrast agent for bone structure analysis. We show that the Eu(III) emission of this complex is not pH dependent within the physiological pH range and its steady state emission is not significantly modulated by a series of group I and II as well as D-metal ions and that this agent can be successfully employed to image mechanically formed cracks (scratches) in bone samples after 4 or 24 h, using confocal laser-scanning microscopy.

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Citations

Dec 6, 2012·Chemical Reviews·Hrvoje Lusic, Mark W Grinstaff
Dec 18, 2013·Chemical Reviews·Marie C HeffernThomas J Meade
Mar 31, 2012·Chemical Research in Toxicology·Claude VidaudDaniel Meyer
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