Selective improvement in renal function preserved remote myocardial microvascular integrity and architecture in experimental renovascular disease.

Atherosclerosis
Victor H Urbieta-CaceresLilach O Lerman

Abstract

Atherosclerotic renovascular disease (ARVD) may impair renal function and increase cardiovascular morbidity and mortality, but the mechanism by which ARVD impacts cardiovascular function is unclear. We tested the hypothesis that preservation of renal function can reverse cardiac dysfunction in ARVD. Endothelial progenitor cells (EPC) were injected intra-renally (ARVD+EPC) after 6 weeks of swine ARVD (concurrent hypercholesterolemia and renovascular hypertension), and single-kidney function and myocardial blood-flow and microvascular permeability (MP) responses to adenosine were assessed using CT 4 weeks later. Myocardial microvascular density was evaluated by micro-CT. Inflammation and oxidative-stress were assessed in kidney venous and systemic blood samples. Normal and untreated ARVD pigs served as controls. Blood pressure was similarly increased in ARVD and ARVD+EPC. Compared to normal, ARVD showed lower glomerular filtration rate, elevated renal vein and systemic oxidized LDL (ox-LDL), aldosterone, uric acid, isoprostanes, transforming growth factor (TGF)-β, and interleukine-6. Renal vein ox-LDL and TGF-β showed a positive gradient across the stenotic kidney, indicating increased renal oxidative stress and fibrogenic activi...Continue Reading

References

Jul 15, 1999·Journal of the American Society of Nephrology : JASN·L O LermanJ C Romero
Dec 3, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J Helmersson, S Basu
Mar 7, 2001·Hypertension·L O LermanJ C Romero
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James D KrierLilach O Lerman
Aug 28, 2002·Circulation·Alejandro R ChadeLilach O Lerman
Apr 2, 2003·Cardiovascular Research·Martin Rodriguez-PorcelLilach O Lerman
Apr 16, 2003·Kidney International. Supplement·Gérard M LondonBruno Pannier
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Jan 26, 2005·Archives of Internal Medicine·Matthew S EdwardsKimberley J Hansen
Apr 12, 2005·Current Opinion in Nephrology and Hypertension·Nancy J Brown
May 2, 2006·American Journal of Hypertension·Tarek Francis Antonios
May 20, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Xiang-Yang ZhuLilach O Lerman
Mar 9, 2007·Journal of the American Society of Nephrology : JASN·Xiang-Yang ZhuLilach O Lerman
Oct 9, 2007·Lancet·José BoggiaUNKNOWN International Database on Ambulatory blood pressure monitoring in relation to Cardiovascular Outcomes (IDACO) investigators
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Josef CoreshAndrew S Levey
Jul 24, 2008·Nature Clinical Practice. Nephrology·Matthias Barton
Jun 23, 2009·Current Opinion in Critical Care·Claudio RoncoFederico Ronco
Jul 25, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Jing LinLilach O Lerman
Dec 18, 2009·The Journal of Clinical Endocrinology and Metabolism·Maria Gabriela Valle GottliebLuiz Carlos Bodanese
Mar 6, 2010·Circulation Research·Ali A Sovari, Samuel C Dudley
Apr 13, 2010·Lancet·Matthew T JamesMarcello Tonelli
Apr 14, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gianni BellomoMario Timio
Sep 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Jiang XuXiao-Ping Yang
Sep 21, 2010·The Journal of Clinical Investigation·Kristina E HootXiao-Jing Wang
Mar 4, 2011·American Journal of Physiology. Renal Physiology·Alfonso EirinLilach O Lerman

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Citations

Oct 29, 2013·American Journal of Hypertension·Kirandeep K KhanguraLilach O Lerman
Jul 3, 2013·Physiology·Alfonso Eirin, Lilach O Lerman
Feb 26, 2015·Hypertension·Lilach O Lerman, Stephen C Textor
Apr 15, 2015·Journal of the American Society of Nephrology : JASN·Stephen C Textor, Lilach O Lerman
Jan 12, 2020·Cardiovascular Research·Oana SoropDirk J Duncker
Jan 31, 2015·Disease Models & Mechanisms·Diana A PapazovaMarianne C Verhaar
Apr 12, 2017·Circulation. Heart Failure·Barry A BorlaugSamuel J Asirvatham

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