Selective induced apoptosis and cell cycle arrest in MCF7 and LNCap cell lines by skin mucus from round goby (Neogobius melanostomus) and common carp (Cyprinus carpio) through P53 expression.

Cytotechnology
Rashid Alijani ArdeshirAmir Parviz Salati

Abstract

The skin mucus in lower vertebrates such as fish with strong innate immune system has many unique and valuable bioactive compounds that can be used for inducing apoptosis in cancer cells. This study was looking for the cytotoxic potential of mucus from the two fish species, including round goby (Neogobius melanostomus) and common carp (Cyprinus carpio), and inducing apoptosis in MCF7 and LNCaP cancer cell lines via influencing P53 gene expression and cell cycle arrest. Results showed that the both mucus types have cytotoxic effects on the both cancer cell lines whereas they have no severe effect on normal primary fibroblast cells. In addition, round goby mucus and common carp mucus selectively induced apoptosis in the LNCaP and MCF7 cells, respectively, through up-regulating P53 gene and arresting cell cycle at the G1 phase. Taken together, this study suggested that the both mucus types can selectively influence P53 pathway and induce apoptosis in especial cancer cells. The skin mucus derived from round Goby and common Carp can be a promising candidate for investigation about apoptosis and molecular targeting therapy in cancer.

References

Aug 7, 1990·Journal of Immunological Methods·M FerrariA M Isetta
Apr 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F ChangK Syrjänen
Feb 5, 1993·Science·J Marx
Aug 1, 1996·Genes & Development·K PolyakB Vogelstein
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 19, 2002·International Journal of Antimicrobial Agents·Claire HellioYves Le Gal
Sep 24, 2005·The FEBS Journal·Gudmundur BergssonGudmundur Hrafn Gudmundsson
Jul 10, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sangeetha SubramanianNeil W Ross
Jun 28, 2008·Planta medica·Alexander D CrawfordPeter A M de Witte
Sep 5, 2009·Nature Reviews. Cancer·David W Meek
Sep 17, 2011·Medicinal Research Reviews·Frederick HarrisDavid A Phoenix
Feb 11, 2016·Computational and Structural Biotechnology Journal·Teerasak E-KobonPramote Chumnanpuen
Mar 5, 2016·Cold Spring Harbor Perspectives in Medicine·Jiandong Chen
Nov 25, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Devesh TewariPawan Kumar Singh

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