Selective inducible nitric oxide synthase (iNOS) inhibition attenuates remote acute lung injury in a model of ruptured abdominal aortic aneurysm

The Journal of Surgical Research
D W HarkinThomas F Lindsay

Abstract

Abdominal aortic aneurysm rupture is associated with a systemic inflammatory response syndrome and acute lung injury. Using a selective inducible nitric oxide synthase (iNOS) inhibitor, N(6)-(iminoethyl)-lysine (L-NIL), we explored the role of iNOS in the early pro-inflammatory signaling and acute lung injury in experimental abdominal aortic aneurysm rupture. Anesthetized rats were randomized to sham control or shock and clamp (s + c) groups, which underwent one hour of hemorrhagic shock, followed by 45 minutes of supramesenteric aortic clamping, and then two hours resuscitated reperfusion. Animals in s + c were randomized to receive intravenous L-NIL at 50 microg/kg/h or saline at the start of reperfusion. Pulmonary permeability to (125)I-labeled albumin, myeloperoxidase (MPO) activity, cytokine levels, and semi-quantitative RT-PCR for mRNA were indicators of microvascular permeability, leuco-sequestration, and pro-inflammatory signaling, respectively. Lung permeability index were significantly increased in s + c compared to sham (4.43 +/- 0.96 versus 1.30 +/- 0.17, P < 0.01), and attenuated by L-NIL treatment (2.14 +/- 0.70, P < 0.05). Lung tissue MPO activity was significantly increased in s + c compared to sham (2.80 +/- 0....Continue Reading

References

Jun 1, 1991·Journal of Applied Physiology·R WelbournH B Hechtman
Dec 1, 1991·Journal of Vascular Surgery·L M HarrisJ J Ricotta
Jun 1, 1991·The British Journal of Surgery·C R WelbournH B Hechtman
Apr 1, 1989·Annals of Surgery·J M KlausnerH B Hechtman
Feb 1, 1989·Annals of Surgery·I S PatersonH B Hechtman
May 1, 1988·The Journal of Trauma·H AnnerH B Hechtman
Mar 1, 1995·Hypertension Research : Official Journal of the Japanese Society of Hypertension·T Chiu, I A Reid
Sep 1, 1995·Journal of Vascular Surgery·T S HuberJ M Seeger
Jul 1, 1994·The Journal of Surgical Research·H AbdihD J Bouchier-Hayes
Sep 1, 1993·American Journal of Surgery·R J BaigrieP J Morris
Nov 1, 1995·The Annals of Thoracic Surgery·M J EppingerG M Deeb
Feb 1, 1997·The Annals of Thoracic Surgery·M S BhabraT L Hooper
Feb 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·M S BhabraT L Hooper
Dec 31, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A B GroeneveldC E Hack
Apr 4, 1998·The Journal of Experimental Medicine·C HierholzerD J Tweardy
Aug 26, 1998·Archives of Orthopaedic and Trauma Surgery·C HierholzerD J Tweardy
Mar 6, 1999·Journal of Applied Physiology·J P WilliamsH B Hechtman
Apr 2, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C U DurakbasaA O Aktan
Sep 25, 1999·Journal of Leukocyte Biology·S CuzzocreaA P Caputi
Jun 30, 2000·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L L LauC V Soong

❮ Previous
Next ❯

Citations

Nov 13, 2008·Pediatric Surgery International·Ahmet GuzelSerap Karasalihoglu
Jun 10, 2011·Journal of Molecular Histology·Sevtap Hekimoglu SahinAli Ozcan
Apr 22, 2005·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·L Staib, D Henne-Bruns
Jun 2, 2009·The Journal of Surgical Research·Alexander D CornetA B Johan Groeneveld
Jun 27, 2006·Transplantation Proceedings·C Zheyu, Y Lunan
Jun 24, 2008·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·P A CowledR A Fitridge
Feb 2, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Quan CaoWenxi Wu
Jul 20, 2016·International Journal of Molecular Medicine·Jae-Won LeeKyung-Seop Ahn
Jun 15, 2007·The Journal of Surgical Research·Prudence A CowledRobert A Fitridge
Jun 25, 2008·International Journal of Pediatric Otorhinolaryngology·Ahmet GuzelSerap Karasalihoglu
Mar 17, 2012·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P SukV Sramek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.