Selective induction of an immune response in human external secretions by ingestion of bacterial antigen

The Journal of Clinical Investigation
J MesteckyJ L Babb

Abstract

Ingestion of capsules which contained killed Streptococcus mutans by four healthy human subjects led to the appearance of specific antibodies in external secretions. Salivary and lacrymal antibodies were detected within 1 wk of ingestion and continued to increase throughout a 14-day immunization period, with a gradual decline during the 2 ensuing months. A second period of immunization resulted in a pronounced increase of specific antibody levels which occurred earlier than in the primary immunization period and reached peak levels by day 10. No change was detected in serum antibody levels throughout either immunization period. The antibody activity in all secretions was associated with the immunoglobulin A class, as determined by immunochemical analyses. These data indicate that ingestion of bacterial antigens selectively stimulates the immune response in secretions.

References

Jul 1, 1977·Journal of Dental Research·M E SchaefferJ R McGhee
Apr 1, 1977·The Journal of Experimental Medicine·M McWilliamsM E Lamm
Mar 17, 1977·Nature·P Brandtzaeg, K Tolo
Apr 1, 1976·La Ricerca in Clinica E in Laboratorio·M Seligmann
Oct 30, 1975·Nature·R M GoldblumA Sohl-Akerlund
Dec 1, 1975·The Journal of Experimental Medicine·C AndréC L Cambiaso
Feb 15, 1969·Nature·R J Genco, M A Taubman
Jun 1, 1974·European Journal of Immunology·D Guy-GrandP Vassalli
Jul 1, 1971·The Journal of Experimental Medicine·S W Craig, J J Cebra
May 1, 1969·Archives of Oral Biology·J CarlssonB Krasse
Apr 18, 1970·Nature·J G Hall, M E Smith

❮ Previous
Next ❯

Citations

Sep 1, 1991·Digestive Diseases and Sciences·J E CrabtreeM S Losowsky
Jan 1, 1984·Folia Microbiologica·J FranĕkV Kubín
Jun 4, 2008·Langenbeck's Archives of Surgery·Joshua L HermsenKenneth A Kudsk
Sep 1, 1995·Veterinary Immunology and Immunopathology·F J WallaceA J Husband
Jan 1, 1992·Research in Microbiology·G RenomP M Martin
Dec 24, 1997·Survey of Ophthalmology·K A McClellan
Aug 26, 1998·Ophthalmology·K A McClellanF A Billson
Jun 6, 2000·Advanced Drug Delivery Reviews·T L Bowersock, S Martin
Apr 26, 2002·Allergy·M K Kägi, B Wüthrich
Apr 16, 1999·Oral Microbiology and Immunology·G Hajishengallis, S M Michalek
May 19, 2001·Oral Microbiology and Immunology·T HarrodM W Russell
Feb 1, 1987·Immunology and Cell Biology·G L Ada, P D Jones
May 27, 2006·Nature Reviews. Immunology·Martin A Taubman, David A Nash
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C CzerkinskyJ Mestecky
Dec 1, 1980·The Journal of Experimental Medicine·S J Challacombe, T B Tomasi
Feb 1, 1983·The Journal of Experimental Medicine·S N EmancipatorM E Lamm
Aug 9, 2002·DNA and Cell Biology·James Chodosh, Ronald C Kennedy
Jun 1, 1995·Oral Microbiology and Immunology·H MarcotteM C Lavoie
Aug 1, 1996·Oral Microbiology and Immunology·P C MontgomeryN L O'Sullivan
Aug 1, 1991·Australian and New Zealand Journal of Medicine·M K Tandon, V Gebski
Dec 1, 1991·Scandinavian Journal of Dental Research·J Olsson, M Svanberg
Feb 25, 1998·Acta Paediatrica·M Xanthou
May 1, 1991·Annals of the Rheumatic Diseases·S O'Mahony, A Ferguson
Mar 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·K A NathavitharanaA S McNeish
Sep 7, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·S M MichalekN K Childers
Mar 15, 2013·Journal of Oral Microbiology·Per Brandtzaeg
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·S P HoganM E Rothenberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.