Selective induction of immunological tolerance in antiviral T killer cells of inbred mice after treatment with cyclosporin A.

Infection and Immunity
D Armerding

Abstract

Primary anti-influenza A cytotoxic thymus-derived (T) and bone marrow (B) lymphocyte-dependent responses in inbred mice were used as an in vivo model system to study the effects of the immunosuppressive fungus metabolite cyclosporin A (CyA). Five consecutive daily oral applications of CyA, with the first being given 1 or 2 h before virus inoculation of the animals, caused a complete blockage of induction of anti-influenza T killer cells and a partial reduction of cytotoxic B lymphocyte activities. Adoptive cell transfer experiments revealed that incapability to respond was due neither to humoral factors nor to the generation of suppressor cells. The tolerance state appeared to be specific for influenza A; cytotoxic T lymphocytes against allogeneic cell surface determinants could be stimulated in immunosuppressed mice. CyA treatment abolished virus-specific and cross-reactive anti-influenza killer T cell responses. Suppression was of short duration: less than 1 week for B cell-dependent functions, and between 1 and 2 weeks for T killer cell responses. Animals appeared to be normal with regard to both of these cellular activities for 4 weeks after tolerance induction. Thus, the data indicate that CyA exerted preferential effects ...Continue Reading

References

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Citations

Jan 1, 1982·Medical Microbiology and Immunology·D ArmerdingE Liehl
Nov 1, 1984·European Journal of Immunology·M F SaronP Truffa-Bachi
Apr 1, 1986·Infection and Immunity·A W HüginR M Zinkernagel
Jan 1, 1991·International Journal of Immunopharmacology·G J Van DaalB Lachmann

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