Selective induction of liver parenchymal cell heme oxygenase-1 in selenium-deficient rats

Biological Chemistry
Volker MostertRaymond F Burk

Abstract

Liver heme oxygenase (HO) activity is higher in selenium-deficient rats than in control animals under basal conditions and is further increased in them, but not in controls, by phenobarbital treatment. In the present study we characterized liver HO induction by selenium deficiency using molecular methods. Severe selenium deficiency in rats caused a doubling of liver HO activity without affecting spleen, kidney, brain, or testis HO activities. HO-1 protein and mRNA were increased to accompany the increased HO activity, but HO-2 protein and mRNA were not increased. Fractionation of the liver into hepatocyte and Kupffer cell/endothelial cell fractions revealed that the increased HO activity resides in the hepatocyte fraction. Immunohistochemical localization of HO-1 protein confirms the induction of HO-1 taking place solely in hepatocytes and throughout the liver lobule. Phenobarbital treatment sharply increased HO-1 mRNA and protein expression in selenium-deficient liver and HO activity in hepatocytes, but had no effect in control liver or in the Kupffer cell/endothelial cell fraction of selenium-deficient liver. Electrophoretic mobility shift assays showed increased AP-1 binding activity, suggesting an involvement of this redox-...Continue Reading

References

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Citations

Feb 1, 2011·Antioxidants & Redox Signaling·Ute JungwirthPetra Heffeter
Sep 10, 2009·Free Radical Research·Andreas S MuellerJosef Pallauf
Sep 6, 2007·Drug Metabolism Reviews·Volker MostertRaymond F Burk
Nov 16, 2004·Trends in Cardiovascular Medicine·Bernd Moosmann, Christian Behl
Jun 11, 2015·Antioxidants & Redox Signaling·Marcus CebulaElias S J Arnér
Feb 19, 2008·Free Radical Biology & Medicine·Raymond F BurkLori M Austin
Dec 20, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Edyta ReszkaWojciech Wasowicz
Jan 11, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kyrylo TronGiuliano Ramadori
Apr 1, 2008·The Biochemical Journal·Aniruddha SenguptaDolph L Hatfield
Oct 8, 2005·The Biochemical Journal·Wendy L TrigonaLorraine M Sordillo
May 30, 2019·Cell Reports·Sun Hee YimVadim N Gladyshev

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