PMID: 41907Nov 1, 1979

Selective influences of age and thyroid hormones on type A monoamine oxidase of the rat heart

The Journal of Pharmacy and Pharmacology
G A Lyles, B A Callingham

Abstract

The specific actiivty of rat heart MAO, towards both tyramine and benzylamine as substrates, was found to increase with the age of the animal, and also after administration of (-)-thyroxine to young male rats. Conversely, enzyme activity was decreased in animals made hypothyroid by including 2-thiouracil in their diet. However, with both age and altered thyroid status, relatively greater changes in the deamination of tyramine rather than in that of benzylamine, were obtained. Clorgyline and deprenyl, used as inhibitors of rat heart MAO, indicated that tyramine is metabolized solely by MAO-A, whereas benzylamine is a substrate for both MAO-A and -B, and also a clorgyline- and deprenyl-resistant enzymic activity. The proportional contribution of MAO-A, -B and the clorgyline-resistant enzyme towards the total benzylamine deamination in the rat heart was found to vary with the age and with altered thyroid status of the animal in such a way that selective changes in the activity of MAO-A appear to be largely responsible for the overall changes in the specific activity of rat heart MAO which occur in response to these developmental factors.

References

Jun 1, 1986·Cellular and Molecular Neurobiology·S B Edelstein, X O Breakefield
Dec 1, 1983·Veterinary Research Communications·B A Callingham
Apr 1, 1987·Mechanisms of Ageing and Development·M MecoF Amenta
Jan 1, 1981·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·C J FowlerA Wiberg
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M YamamotoK Oguchi
Dec 31, 2003·Neurotoxicology·Antonietta NicotraOrnella Senatori
Apr 1, 1982·Journal of Neurochemistry·E J Harris, M B Cooper
Dec 1, 1980·The Journal of Pharmacy and Pharmacology·D ParkinsonB A Callingham

Citations

Dec 2, 1976·Biochimica Et Biophysica Acta·A J HulbertJ K Raison
Sep 1, 1975·The Journal of Pharmacy and Pharmacology·G A Lyles, B A Callingham
Nov 15, 1977·Biochemical Pharmacology·J A Fuentes, N H Neff
Jan 1, 1978·Biochemical Pharmacology·T J Mantle, K F Tipton
Jan 1, 1976·Journal of Neural Transmission·M B Youdim, M Holzbauer
Mar 1, 1977·Biochemical Pharmacology·L D Corte, B A Callingham
Dec 1, 1973·The Journal of Pharmacy and Pharmacology·B A Callingham, R Laverty
Dec 1, 1974·The Journal of Pharmacy and Pharmacology·G A Lyles, B A Callingham
Oct 1, 1972·Journal of Neurochemistry·A VaccariF Cugurra
Sep 1, 1971·Neuropharmacology·C Goridis, N H Neff
Jan 1, 1971·Journal of Neurochemistry·B Jarrott
Jul 1, 1968·Biochemical Pharmacology·J P Johnston
Mar 1, 1967·Canadian Journal of Biochemistry·A Ho-Van-HapL Berlinguet
Jul 22, 1967·Nature·A Horita
Jan 1, 1953·Scandinavian Journal of Clinical and Laboratory Investigation·J GOA

Related Concepts

Myocardium
Senility
Monoamine Oxidase
Hypothyroidism
Substrate Specificity
Heart
Selegiline, (S)-Isomer
Maob
Maoa
Thyroid Hormones

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