Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice.

Drug Design, Development and Therapy
Huashan LiJuanmin Zha

Abstract

The effect of 11β-hydroxysteroid dehydrogenase type1 (11β-HSD1) inhibition on hepatic steatosis is incompletely understood. Here, we aimed to determine the therapeutic effect of BVT.2733, a selective 11β-HSD1 inhibitor, on hepatic steatosis. C57B/6J mice were randomly divided into a low-fat diet (LFD) fed group and a high-fat diet (HFD) fed group. Mice were fed with HFD for 28 weeks which induced obesity and severe hepatic steatosis. The two groups were further divided into four groups as follows: LFD, LFD with BVT.2733, HFD, and HFD with BVT.2733. Mice in LFD+BVT and HFD+BVT groups were intraperitoneally injected with BVT.2733 daily for 30 days. Effects of BVT.2733 on mice body weight, serum lipid profile, serum free fatty acids (FFAs), glucocorticoid levels, gene expression in adipose and liver tissues were assessed. Injection of a low dose of BVT.2733 (50 mg/kg/day) reduced body weight and hyperlipidemia, but did not improve glucose tolerance and insulin resistance in diet-induced obese mice. The low dose of BVT.2733 attenuated hepatic steatosis, liver injury, and liver lipolytic gene expression in diet-induced obese mice. Besides, the low dose of BVT.2733 reduced fat mass and lipolysis in visceral adipose tissues, hepatic F...Continue Reading

References

Jan 22, 2000·Annals of Internal Medicine·S BellentaniC Tiribelli
May 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Janice M PatersonJohn J Mullins
Apr 25, 2008·The Journal of Endocrinology·David P MacfarlaneBrian R Walker
Apr 25, 2008·The Journal of Endocrinology·I J BujalskaP M Stewart
Jul 16, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David van der PoortenJacob George
Feb 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M BerthiaumeY Deshaies
Aug 7, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Mohsen Ibrahim
Jan 29, 2010·American Journal of Physiology. Cell Physiology·Mandeep P GaidhuRolando B Ceddia
Oct 15, 2010·American Journal of Physiology. Cell Physiology·Jonathan E CampbellMichael C Riddell
Dec 6, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Roberto CandiaMarco Arrese
Mar 6, 2013·Nature Reviews. Gastroenterology & Hepatology·Geoffrey C FarrellShiv Chitturi
Mar 4, 2014·World Journal of Gastroenterology : WJG·Xue-Qun ZhangYou-Ming Li
Apr 29, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghRohit Loomba
Apr 30, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fernando BrilKenneth Cusi
Jun 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Stuart A MorganGareth G Lavery
Jan 7, 2015·World Journal of Gastroenterology : WJG·Sanja StojsavljevićMarko Duvnjak
Apr 15, 2015·The Journal of Endocrinology·Eun Hee KohKi-Up Lee
Mar 22, 2016·Metabolism: Clinical and Experimental·Yousef FazelZobair M Younossi
Oct 22, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiRachel Beckerman
Dec 19, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiantong ZouZoi Michailidou
Feb 3, 2018·Advanced Drug Delivery Reviews·Qiaozhu SuRam I Mahato
Jun 26, 2018·Journal of Hepatology·Cynthia LebeaupinBéatrice Bailly-Maitre
Jul 4, 2018·Nature Medicine·Scott L FriedmanArun J Sanyal
Oct 7, 2018·Journal of Molecular and Cellular Cardiology·Min HuangGuoxian Ding

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.