PMID: 6407870Jul 11, 1983Paper

Selective inhibition of 5-lipoxygenase by natural compounds isolated from Chinese plants, Artemisia rubripes Nakai

FEBS Letters
Y KoshiharaT Tatsuno

Abstract

Three of four natural compounds, which are caffeic acid, eupatilin and 4'-demethyleupatilin, isolated from Chinese plant, Artemisia rubripes Nakai selectively inhibited 5-lipoxygenase of cultured mastocytoma cells. Half-inhibition doses (ID50) for caffeic acid, eupatilin and 4'-demethyleupatilin were 3.7, 14 and 18 X 10(-6) M, respectively. The inhibition by caffeic acid was non-competitive types. Prostaglandin synthase activities were little inhibited by eupatilin and 4'-demethyleupatilin, but rather stimulated by caffeic acid. The formation of leukotriene C4 and D4 by mast tumor cells was almost completely suppressed by these compounds at 10(-4) M.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R C MurphyB Samuelsson
Jul 1, 1981·Biochemical Pharmacology·Y KoshiharaS Murota
Jun 1, 1983·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·A LaoT Tatsuno
Mar 21, 1980·Biochimica Et Biophysica Acta·Y KoshiharaS I Murota

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Citations

Oct 4, 1984·Biochimica Et Biophysica Acta·M FurukawaS Yamamoto
Jan 1, 1991·Biochemical Pharmacology·G R ReddyT Nomura
Jul 7, 1992·Biochemical Pharmacology·C VossF W Zilliken
Dec 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J V Formica, W Regelson
Dec 6, 2005·Journal of Toxicology and Environmental Health. Part a·Ji Young KimJai Youl Ro
May 1, 2008·Journal of Gastroenterology and Hepatology·Sang Woon ParkKi Baik Hahm
Apr 17, 2010·Molecular Nutrition & Food Research·Kyung-Sook ChungKyung-Tae Lee
Apr 25, 2015·Behavioral and Brain Functions : BBF·Guojuan LiangJunqing Yang
Apr 4, 2007·Annals of the New York Academy of Sciences·Min-Jung KimYoung-Joon Surh
Jun 10, 2015·European Journal of Pharmacology·Sabindra Pradhananga, Won-Sik Shim
May 26, 2007·The Journal of Pharmacy and Pharmacology·Jianghong TangWeihua Li
Aug 19, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H S LeeS Y Kim
Nov 3, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jae Chun LimUy Dong Sohn
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Oct 8, 2016·Chemical Biology & Drug Design·Jérémie A DoironMohamed Touaibia
Apr 15, 2020·International Journal of Molecular Sciences·Silvia ZappavignaMichele Caraglia
Mar 1, 2020·Archives of Biochemistry and Biophysics·Keisuke TodaToshiko Suzuki-Yamamoto
May 16, 2021·Bioorganic & Medicinal Chemistry Letters·Aravind R NesaragiVijay M Kumbar
Nov 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K MatsumotoS Murota
Sep 1, 1984·The Journal of Allergy and Clinical Immunology·S YamamotoS Watanabe-Kohno

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