Selective inhibition of early axonal regeneration by myelin-associated glycoprotein

Experimental Neurology
Kojun Torigoe, G Lundborg

Abstract

When the distal stump of a transected peripheral nerve is brought into the vicinity of the proximal nerve stump, the regenerating axons advance toward it across the gap. Similar results are obtained when a predegenerated nerve segment is used. However, when a nerve segment subjected to proximal axotomy 7 days earlier (7-day nerve segment) was placed close to the proximal end of a freshly cut nerve at a distance of less than 1.5 mm, there were neither regenerating axons nor sprouts. The same inhibition of axonal regeneration was also exhibited when a nerve segment subjected to axotomy 9 to 14 days earlier was used. To examine the inhibitory effect of the nerve segments on established regenerating axons, we positioned a 7-day nerve segment in close apposition to a proximal nerve end at 2 or 3 days after transection. The growth of the 3-day-old regenerating axons, already ensheathed by Schwann cells, was not disturbed, but the 2-day-old regenerating axons, consisting of naked axons, were eliminated by the 7-day nerve segment. It is assumed that the findings reflect a mechanism serving to eliminate abundant sprouts and immature axons, probably conferring optimum regeneration and maturation of outgrowing pioneer axons. The inhibitor...Continue Reading

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Citations

Oct 13, 2006·Archives of Histology and Cytology·Hideki TsuyoshiShigeki Hirano
Jul 22, 2008·Neurobiology of Disease·Kenneth MinorStephen J Davies
Sep 12, 2006·Progress in Retinal and Eye Research·Alan R HarveyQi Cui
Dec 17, 2008·Neurological Research·Lynda J-S Yang, Ronald L Schnaar
Aug 13, 2013·Experimental Neurology·M AbdullahT M Brushart
Apr 5, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Maria AuerLars Klimaschewski
Jan 29, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Elaine A IrvingAndrew A Parsons
Feb 24, 2017·Stroke; a Journal of Cerebral Circulation·Steven C CramerThomas R Thompson
Sep 24, 2020·Cells·Sara BolívarEsther Udina
Apr 1, 2003·The Canadian Journal of Plastic Surgery = Journal Canadien De Chirurgie Plastique·Terence M MyckatynSusan E Mackinnon
Apr 12, 2000·Journal of Neuropathology and Experimental Neurology·S T HsiehW M Lin
May 26, 2004·Archives of Biochemistry and Biophysics·Ronald L Schnaar

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