PMID: 6401767Feb 1, 1983Paper

Selective inhibition of follicle-stimulating hormone secretion by estradiol. Mechanism for modulation of gonadotropin responses to low dose pulses of gonadotropin-releasing hormone

The Journal of Clinical Investigation
J C MarshallR P Kelch

Abstract

Prepubertal girls and gonadotropin-releasing hormone (GnRH)-deficient females secrete follicle-stimulating hormone (FSH) preferentially in response to intravenous GnRH. With continued pulsatile GnRH stimulation, FSH secretion is reduced when plasma estradiol (E2) is increasing. To delineate the mechanisms involved in these changing gonadotropin responses, e studied the effect of low dose (0.025 micrograms/kg) pulsatile injections of GnRH in females with varying degrees and/or duration of endogenous GnRH deficiency (idiopathic panhypopituitarism, PHP; isolated growth hormone deficiency, IGHD; isolated gonadotropin deficiency, IGD; and anorexia nervosa, AN; both at low body weight and after weight regain). In patients presumed to have the most severe GnRH deficiency (PHP), responses of both FSH and luteinizing hormone (LH) were small and delayed, and no increase in plasma estradiol occurred during the 5 d of GnRH injections. In patients previously exposed to prepubertal or adult levels of endogenous GnRH secretion (IGHD, IGD, AN at low body weight), a rapid initial FSH response occurred that subsequently declined when plasma estradiol rose to concentrations greater than 40-50 pg/ml. Prior therapy with estrogen (micronized estradi...Continue Reading

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Citations

Feb 19, 2011·European Journal of Applied Physiology·Antonia Mestre-AlfaroAntoni Pons
Jun 3, 1999·Endocrinology and Metabolism Clinics of North America·J C Marshall, C A Eagleson
Dec 4, 1986·The New England Journal of Medicine·J C Marshall, R P Kelch
Jan 20, 1991·The New England Journal of Medicine·P M Conn, W F Crowley
Jan 1, 1994·Annual Review of Medicine·P M Conn, W F Crowley
Feb 6, 2010·The Journal of Clinical Endocrinology and Metabolism·N D ShawJ E Hall
Dec 18, 1998·Journal of Endocrinological Investigation·J E HallW F Crowley
Oct 13, 2007·International Journal of Andrology·Anne Cailleux-BounacerJean Marc Kuhn
Feb 26, 2016·Asian Journal of Andrology·Michael SchulsterRanjith Ramasamy
Aug 14, 1986·The New England Journal of Medicine·S E MacConnieI Z Beitins
Sep 1, 1987·Metabolism: Clinical and Experimental·J M HartnellJ M Hershman
Jan 1, 1989·Annals of the New York Academy of Sciences·N K MelloS K Teoh
Oct 16, 2008·The Journal of Clinical Endocrinology and Metabolism·David M RobertsonHenry G Burger
May 24, 2003·Journal of Midwifery & Women's Health·Elisabeth H Quint, Yolanda R Smith
Jul 31, 2020·Journal of Ethnopharmacology·Fernanda Carolina Ribeiro DiasSérgio Luis Pinto da Matta

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