Selective inhibition of gastrulation in the starfish embryo by albuside B, an inosine analogue

FEBS Letters
T ShimizuMarina Dan-Sohkawa

Abstract

External application of 0.2-100 micrograms/ml albuside B inhibits gastrulation of the starfish (Asterina pectinifera) embryo. Treated embryos retain the late blastula morphology with the vegetal plate. However, the vegetal plate is unreactive to soybean agglutinin, a probe for observing the progenitor cells of the archenteron (mesendoderm) in a normal embryo. The effective period of the treatment is limited from 4 to 6 h after fertilization, a period immediately before the onset of blastulation. RNA synthesis is unaffected during the period of sensitivity. The selectivity of the inhibition shows that albuside B may be a useful tool for studying the mechanisms of mesendoderm differentiation.

References

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Citations

Apr 16, 2002·European Journal of Biochemistry·Hiroyuki SuginoSusumu Ikegami
Sep 5, 2021·Development, Growth & Differentiation·Sohei SuzukiHiroyuki Kaneko

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