Selective inhibition of interleukin-8-induced neutrophil chemotaxis by ketoprofen isomers

Biochemical Pharmacology
Cinzia BizzarriRiccardo Bertini

Abstract

Although it is commonly accepted that the anti-inflammatory effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is mainly associated to their ability to inhibit the cyclooxygenase (COX) enzyme system, several results indicate that non-COX mechanisms could be important in the therapeutical effect of these drugs. The aim of this study was to define if NSAIDs could exert, at least in part, their anti-inflammatory effect by inhibiting the activities of human polymorphonuclear leukocytes (PMNs) triggered by chemotactic stimuli and, if so, to understand the relationship of this effect with COX inhibition. A unique opportunity to dissociate the inhibition of prostaglandin (PG) synthesis from other therapeutical properties of NSAIDs is constituted by ketoprofen isomers being the S-isomer 100 time more potent than R-isomer on COX inhibition. Our results show that R- and S-ketoprofen, independently of their potency as PG inhibitors, proved very efficacious in selective inhibition of interleukin-8 (IL-8) chemotaxis. Inhibition of IL-8 chemotaxis was not restricted to ketoprofen isomer as it could be observed also with drugs belonging to different classes of NSAIDs and it was obtained at drug concentration superimposable to plasma leve...Continue Reading

References

Feb 1, 1979·Prostaglandins·J T O'FlahertyP A Ward
Oct 1, 1992·Journal of Clinical Pharmacology·K BruneS Menzel-Soglowek
Feb 1, 1991·The Journal of Clinical Investigation·M SeitzM Baggiolini
Jan 1, 1989·Arthritis and Rheumatism·S B Abramson, G Weissmann
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S AbramsonG Weissmann
Feb 1, 1987·Immunopharmacology·V G Nielsen, R O Webster
Dec 3, 1971·Nature·R B Zurier, F Quagliata
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Jun 15, 1983·Biochemical and Biophysical Research Communications·J C Fantone, D A Kinnes
Jan 1, 1980·Journal of Immunological Methods·W FalkE J Leonard
Jul 1, 1994·Trends in Biochemical Sciences·J AvruchJ M Kyriakis
Mar 1, 1993·British Journal of Clinical Pharmacology·M VillanuevaK Schrör
Feb 2, 1996·The Journal of Biological Chemistry·C KnallG L Johnson
Oct 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B B DamajP H Naccache
Mar 28, 1998·British Journal of Pharmacology·N ScheurenA Pahl
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·M H PillingerG Weissmann
Feb 11, 1999·Biochemical Pharmacology·M HeimbürgerJ Palmblad

❮ Previous
Next ❯

Citations

Jul 26, 2005·Infection and Immunity·M Rambeaud, G M Pighetti
Sep 14, 2004·American Journal of Respiratory and Critical Care Medicine·Wan C TsaiTheodore J Standiford
Nov 15, 2011·BMC Immunology·Saulius PaskauskasEduard Ryschich
Feb 11, 2005·Journal of the American Veterinary Medical Association·Jean-Jacques Kona-BounEric Troncy
Jul 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Riccardo BertiniFrancesco Colotta
May 18, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·E H NafeaP J Martens
Feb 22, 2013·Expert Opinion on Therapeutic Targets·Kathleen M HertzerO Joe Hines
Nov 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Alessio MoriconiMarcello Allegretti
Mar 15, 2014·Experimental Biology and Medicine·Nithin B BoppanaShukkur M Farooq
Feb 11, 2014·Current Protocols in Toxicology·Kathryn M PietrosimoneMichael A Lynes
Mar 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Huapeng FanMichael J Hickey
Sep 24, 2018·Journal of Dairy Science·Denisa DanOlga Wellnitz
Jun 25, 2005·Journal of Medicinal Chemistry·Marcello AllegrettiFrancesco Colotta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Related Papers

Current Opinion in Gastroenterology
Oscar J Hines, Howard A Reber
The Journal of Immunology : Official Journal of the American Association of Immunologists
Sibylle von VietinghoffKlaus Ley
© 2021 Meta ULC. All rights reserved