PMID: 9163322Apr 15, 1997Paper

Selective inhibition of mitochondrial respiration and glycolysis in human leukaemic leucocytes by methylglyoxal

The Biochemical Journal
S BiswasS Ray

Abstract

The effect of methylglyoxal on the oxygen consumption of mitochondria of both normal and leukaemic leucocytes was tested by using different respiratory substrates and complex specific artificial electron donors and inhibitors. The results indicate that methylglyoxal strongly inhibits mitochondrial respiration in leukaemic leucocytes, whereas, at a much higher concentration, methylglyoxal fails to inhibit mitochondrial respiration in normal leucocytes. Methylglyoxal strongly inhibits ADP-stimulated alpha-oxoglutarate and malate plus NAD+-dependent respiration, whereas, at a higher concentration, methylglyoxal fails to inhibit succinate and alpha-glycerophosphate-dependent respiration. Methylglyoxal also fails to inhibit respiration which is initiated by duroquinone and cannot inhibit oxygen consumption when the N,N,N', N'-tetramethyl-p-phenylenediamine by-pass is used. NADH oxidation by sub-mitochondrial particles of leukaemic leucocytes is also inhibited by methylglyoxal. Lactaldehyde, a catabolite of methylglyoxal, can exert a protective effect on the inhibition of leukaemic leucocyte mitochondrial respiration by methylglyoxal. Methylglyoxal also inhibits l-lactic acid formation by intact leukaemic leucocytes and critically re...Continue Reading

Citations

Aug 26, 2014·Toxicology and Applied Pharmacology·Kyuhwa SeoSang Mi Shin
Jan 6, 2009·Molecular Nutrition & Food Research·Sara Rodríguez-EnríquezRafael Moreno-Sánchez
Dec 10, 2013·Free Radical Biology & Medicine·Pamela Boon Li PunMichael P Murphy
May 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Monika Paul-SamojednyJan Kowalski
Aug 22, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Etelvino J H BecharaNilson A Assunção
Mar 8, 2006·Free Radical Biology & Medicine·Susana Garcia de ArribaClemens Allgaier
Jul 11, 2012·International Journal of Cell Biology·Pamela Boon Li Pun, Michael P Murphy
Dec 22, 2016·International Journal of Molecular Sciences·Antje HutschenreutherGerd Birkenmeier
Jan 24, 2017·Toxicology Mechanisms and Methods·Alessandro de Souza PrestesNilda Vargas Barbosa
Apr 6, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Kazuki AkiraTakao Hashimoto
Mar 29, 2006·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Vladimir L Voeikov
Nov 18, 2009·Biochemistry. Biokhimii︠a︡·D TalukdarS Ray
Sep 28, 2013·Journal of Bioenergetics and Biomembranes·Aleksandr KlepininTuuli Kaambre
Oct 3, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Jadwiga PietkiewiczRegina Danielewicz
Feb 13, 2009·American Journal of Physiology. Renal Physiology·Takanori KumagaiReiko Inagi
Jun 13, 2002·American Journal of Physiology. Renal Physiology·Mariana G RoscaMiriam F Weiss
Sep 12, 2001·The International Journal of Biochemistry & Cell Biology·F AmicarelliA M Ragnelli

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