Selective inhibition of nitric oxide synthase causes increased muscle thickness in rat esophagus

Journal of Pediatric Surgery
Tutku SoyerPinar Atasoy

Abstract

Achalasia is a primary motor dysfunction of esophagus which can be created experimentally by nitric oxide synthase (NOS) inhibition. Although several theories have been suggested, mechanism of increased esophageal muscle thickness in achalasia is still unclear. An experimental study was performed to evaluate the esophageal muscle thickness after selective inhibition of NOS in rats. Wistar albino rats (n=18) weighing 150-200g of both sexes were included in the study. After anesthetization with ketamine hydrochloride, esophageal body and distal esophagus were sampled in control group (CG, n=6). In sham group (SG, n=6), intraperitoneal saline (1ml) injection was performed for 21days. l-NAME (l-nitroarginin metyl ester, selective inhibitor of NOS) group (LNAMEG, n=6) received 100mg/kg/d l-NAME intraperitoneally for 21days. The esophageal body and distal esophagus were removed for histopathological analysis in each group. All samples were evaluated for total and circular muscle thickness with hemotoxylene-eosine (HE) staining. None of the samples showed pathologic finding in esophageal mucosa. There was no difference between CG and SG for total and circular muscle thickness in esophageal body and distal esophagus. LNAMEG had higher ...Continue Reading

References

Sep 15, 2001·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·I KarnakN Büyükpamukçu
Feb 18, 2006·Biochemical and Biophysical Research Communications·Fumi MomotaHideo Kanaide
May 15, 2013·Journal of Neurogastroenterology and Motility·Ravinder K MittalValmik Bhargava

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Citations

Aug 15, 2018·Anatomia, histologia, embryologia·Liliana RytelJoanna Wojtkiewicz
Dec 6, 2017·International Journal of Molecular Medicine·Chi-Jung HuangYen-Chieh Wang

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