Selective inhibition of noradrenaline and serotonin uptake by C 49802-B-Ba and CGP 6085 A

European Journal of Pharmacology
P C WaldmeierL Maitre


The effects of two new compounds, 1-(1-methylamino-2-hydroxy-3-propyl)-dibenzo[b,e]bicyclo[2,2,2]octadiene-HCl (C 49802-B-Ba) and 4-(5,6-dimethyl-2-benzofuranyl) piperidine HCl (CGP 6085 A), on noradrenaline (NA) and serotonin (5-HT) uptake were investigated in different test systems, CGP 6085 A is a very potent and selective inhibitor of 5-HT uptake in rat brain (ED50 1-4 mg/kg p.o., depending on test system). Doses up to 1000 mg/kg p.o. did not inhibit NA uptake. C 49802-B-Ba is a potent and selective inhibitor of NA uptake in rat brain (ED50 5-10 mg/kg p.o. depending on test system) and heart (ED50 1.5 mg/kg p.o.). At 300 mg/kg p.o., this compound caused no inhibition of 5-HT uptake.


Mar 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·R OrtmannA Delini-Stula
Dec 16, 1983·Pharmaceutisch Weekblad. Scientific Edition·C J GrolJ De Vries
May 15, 1979·European Journal of Pharmacology·P C Waldmeier, A Delini-Stula
Dec 20, 1979·European Journal of Pharmacology·P C Waldmeier
Mar 12, 1985·European Journal of Pharmacology·W A WolfD M Kuhn
Aug 1, 1980·Physiology & Behavior·W KostowskiA Płaźnik
May 1, 1993·Pharmacology, Biochemistry, and Behavior·S F LeibowitzG F Weiss
Sep 1, 1982·Journal of Affective Disorders·J E De Wilde, D P Doogan
Jun 1, 1993·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A SteigerF Holsboer
Apr 1, 1997·Physiology & Behavior·K InoueS Yamagami
Jan 21, 2000·Brain Research. Molecular Brain Research·Y RenN Saito
Oct 1, 1993·Journal of Basic and Clinical Physiology and Pharmacology·D VaronN V Kaverina
Dec 1, 1982·British Journal of Clinical Pharmacology·O SchmidlinE Weber
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·E C KulakowskiW Lovenberg
Apr 1, 1984·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·W DieterleJ Wagner

Related Concepts

Bicyclo Compounds
Bridged Compounds
Depression, Chemical
Norepinephrine, (+, -)-Isomer

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.