Selective inhibition of the lipoxygenase metabolic pathway of arachidonic acid by the SRS-A antagonist, FPL 55712

Prostaglandins
F B CaseyD C Buck

Abstract

Arachidonic acid, metabolized by the enzyme contained in the cell-free homogenate of rat basophilic leukemia (RBL-1) cells, yields products of both the lipoxygenase and cyclooxygenase pathways. FPL 55712, the SRS-A antagonist, was found to inhibit the formation of lipoxygenase products, but not the cyclooxygenase products. Proxicromil was qualitatively similar, but markedly less potent. Disodium cromoglycate was inactive as an inhibitor of either metabolic pathway at concentrations up to 300 microM.

References

Dec 1, 1978·The Journal of Allergy and Clinical Immunology·R PattersonK E Harris
Jun 15, 1979·Biochemical Pharmacology·G A HiggsJ R Vane
Jan 1, 1978·Biochemical Pharmacology·M Chasin, C Scott
Sep 1, 1979·The American Journal of Medicine·A Wanner
Jan 1, 1977·Acta Anaesthesiologica Scandinavica·K Pavek
Nov 17, 1977·Nature·G K Adams, L M Lichtenstein
Oct 1, 1977·Agents and Actions·J AugsteinP Sheard
Oct 17, 1973·Nature: New Biology·J AugsteinM L Tattersall
Sep 4, 1980·Nature·B A Jakschik, L H Lee
Dec 1, 1980·The Journal of Pharmacy and Pharmacology·J R WalkerW Dawson
Apr 9, 1981·European Journal of Pharmacology·J F Burka, N A Paterson
Jul 16, 1980·Biochemical and Biophysical Research Communications·B A JakschikM M Steinhoff
Feb 1, 1981·Prostaglandins·A F WeltonB Yaremko
Dec 17, 1981·European Journal of Pharmacology·J M HandC K Buckner
Jul 1, 1981·Agents and Actions·D M RitchieM E Rosenthale
Apr 18, 1980·Biochimica Et Biophysica Acta·M M SteinhoffB A Jakschik
Feb 1, 1953·Archives of Biochemistry and Biophysics·A L TAPPELP D BOYER
Sep 1, 1981·Biochemical Pharmacology·G FolcoE Graström

❮ Previous
Next ❯

Citations

Jun 1, 1986·Agents and Actions·J H MusserA J Lewis
Mar 21, 1986·Biochimica Et Biophysica Acta·A M Gilfillan, S A Rooney
Nov 21, 1983·Life Sciences·M M Goldenberg, E M Subers
Dec 1, 1983·Prostaglandins·Y AshidaY Maki
Oct 1, 1987·Prostaglandins, Leukotrienes, and Medicine·O W TawfikS K Dey
Apr 1, 1991·European Journal of Clinical Investigation·E GulbinsM Steinhausen
Jul 1, 1989·American Journal of Respiratory Cell and Molecular Biology·H W FarberF L Glauser
Nov 15, 1983·Biochemical and Biophysical Research Communications·G K HogaboomS T Crooke
Jul 16, 2003·American Journal of Obstetrics and Gynecology·Roberta B Ness
Jun 1, 1985·Journal of Autonomic Pharmacology·G Feuerstein
Jul 1, 1988·Pflügers Archiv : European journal of physiology·J HellerS Kamarádová

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.