PMID: 9190460May 7, 1997Paper

Selective inhibitors of cyclooxygenase-2. New agents against pain and inflammation

Läkartidningen
E Oliw

Abstract

Peripherally active analgesics are considered to exert their effect by blocking the enzyme, cyclo-oxygenase (COX), thus inhibiting the biosynthesis both of prostaglandins and of thromboxanes. It was recently found that there are two enzymes which can form prostaglandins: COX-1 and COX-2. Whereas COX-1 is normally expressed in many tissues, expression of COX-2 can be induced in response to inflammation. New experimental findings in 'knockout' mice have suggested that subgrouping of cyclo-oxygenases as 'good' (COC-1) and 'bad' (COX-2) may be inappropriate. COX-2 specific NSAIDs (non-steroidal anti-inflammatory drugs) may be potent antiinflammatory and analgesic agents with no serious side-effects, though this has yet to be confirmed in clinical trials.

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Journal of the National Cancer Institute
Makoto M Taketo
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Naomi L ChillingworthLucy F Donaldson
Journal of the National Cancer Institute
Makoto M Taketo
© 2021 Meta ULC. All rights reserved