Selective laser sintering scaffold with hierarchical architecture and gradient composition for osteochondral repair in rabbits

Biomaterials
Yingying DuShengmin Zhang

Abstract

Osteochondral defects cannot be adequately self-repaired due to the presence of the sophisticated hierarchical structure and the lack of blood supply in cartilage. Thus, one of the major challenges remaining in this field is the structural design of a biomimetic scaffold that satisfies the specific requirements for osteochondral repair. To address this hurdle, a bio-inspired multilayer osteochondral scaffold that consisted of the poly(ε-caprolactone) (PCL) and the hydroxyapatite (HA)/PCL microspheres, was constructed via selective laser sintering (SLS) technique. The SLS-derived scaffolds exhibited an excellent biocompatibility to support cell adhesion and proliferation in vitro. The repair effect was evaluated by implanting the acellular multilayer scaffolds into osteochondral defects of a rabbit model. Our findings demonstrated that the multilayer scaffolds were able to induce articular cartilage formation by accelerating the early subchondral bone regeneration, and the newly formed tissues could well integrate with the native tissues. Consequently, the current study not only achieves osteochondral repair, but also suggests a promising strategy for the fabrication of bio-inspired multilayer scaffolds with well-designed archit...Continue Reading

Citations

Apr 13, 2018·Biomedizinische Technik. Biomedical Engineering·Chunrong YangGuangyu Kang
May 16, 2018·Molecular Biotechnology·Nadeem SiddiquiSreenivasa Rao
Sep 23, 2018·Journal of Biomedical Materials Research. Part a·Jiali ShenMingqing Chen
Jan 5, 2019·Tissue Engineering. Part B, Reviews·Shi ShenNaiqiang Zhuo
Oct 3, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaolei NieDong-An Wang
Feb 19, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yafang ChenXingdong Zhang
Mar 25, 2020·Journal of Biomaterials Science. Polymer Edition·Weiwei LanWeiyi Chen
Jun 25, 2019·Npj Regenerative Medicine·Anthony R MartínRobert L Mauck
Jul 19, 2020·Polymers·Victor Perez-PuyanaAntonio Guerrero
Aug 4, 2020·Advanced Healthcare Materials·You ChenJie Liu
Aug 11, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bin ZhangRoger J Narayan
Aug 15, 2020·Biochemical Society Transactions·Mark LemoineFergal J O'Brien
Nov 7, 2019·Journal of Clinical Medicine·Aurelio SalernoPaolo Antonio Netti
Sep 12, 2020·Pharmaceutics·Tania LimongiEnzo di Fabrizio
Jan 29, 2019·Journal of Materials Science. Materials in Medicine·Saba Abdulghani, Pedro G Morouço
Mar 25, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sven H DiermannHan Huang
Sep 24, 2019·Journal of Toxicology and Environmental Health. Part a·Mauro PetrettaLivia Roseti
Oct 30, 2019·Bioengineering·Christina KryouIoanna Zergioti
Feb 23, 2020·Biochemistry Research International·Xiangbo MengXinluan Wang
Feb 28, 2019·Journal of Tissue Engineering and Regenerative Medicine·Swati MidhaSujata Mohanty
Aug 24, 2018·Journal of Functional Biomaterials·Ludovica ParisiGuido M Macaluso
Mar 7, 2020·Polymers·Víctor Santos-RosalesCarlos A García-González
Dec 22, 2019·Applied Biochemistry and Biotechnology·Xueyan HuKedong Song
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Saeed MiraminiLauren E J Thomas-Seale
Dec 22, 2020·Regenerative Engineering and Translational Medicine·Mohammed A BarajaaCato T Laurencin
Feb 2, 2021·Journal of Orthopaedic Translation·Sida LiaoShibi Lu
Feb 2, 2021·Current Opinion in Biomedical Engineering·Hyun KimSyam P Nukavarapu

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