Selective left ventricular adriamycin-induced cardiomyopathy in the pig

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Stefan ChristiansenRüdiger Autschbach

Abstract

The aim of this study was the development of an experimental cardiomyopathy induced with Adriamycin (Pharmacia & Upjohn, Erlangen, Germany) with selective toxic damage of the left ventricular myocardium that avoided an ischemic component. An intracoronary catheter was implanted directly into the left main stem in pigs and connected to a percutaneous access port that was used for repetitive Adriamycin administration (3-5 x 25 mg weekly over a 1-hour period). Hemodynamic and echocardiographic variables were measured before Adriamycin administration, 1 week after, and at 4 weeks. Thereafter, all hearts were autopsied for detailed histologic examination. Statistical analysis was done by an analysis of variance for multiple parameters. All pigs had normal baseline cardiac function. Measurements after Adriamycin administration and 4 weeks later demonstrated a continued increase of the central venous pressure, pulmonary artery pressure, pulmonary wedge pressure, and pulmonary vascular resistance, whereas cardiac output, stroke volume index, and left ventricular stroke work index decreased. These results were supported by the echocardiographic data depicting an increase of left ventricular diameters and volumes, accompanied by a decrea...Continue Reading

References

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Jul 8, 1998·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·H R ShahM Chiavarelli
Mar 14, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Stefan ChristiansenDieter Hammel
Jan 24, 2006·Journal of Cardiac Surgery·Nicolas BorensteinValérie Chetboul

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Citations

Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Andreas GoetzenichStefan Christiansen
Jun 30, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Stefan Christiansen
Apr 16, 2015·Texas Heart Institute Journal·Ana Maria SeguraL Maximilian Buja
Dec 11, 2020·Science Translational Medicine·Kenta HiraiHidemasa Oh
Feb 20, 2021·Cardiovascular Research·Carlos Galán-ArriolaBorja Ibanez

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