Abstract
We investigated the effects of a selective lesion of the substantia nigra pars reticulata (SNr), obtained by stereotaxic injection of ibotenic acid, on the cortical expression of Fos protein induced by striatal infusion of dopamine, D1-like agonist SKF 38393, in Sprague-Dawley rats. The specific aim was to clarify the role of the basal ganglia output structures - SNr in particular - in the cortical activation that follows a D1-dependent activation of the striatofugal, direct pathway, in freely moving animals. The striatal, unilateral infusion of 30 mM SKF 38393 induced consistent Fos expression throughout the whole ipsilateral cerebral cortex, including motor, sensorimotor, associative, and limbic areas; such expression was dramatically reduced by excitotoxic lesion of the ipsilateral SNr. These findings confirm the prominent role of the SNr in the transmission of striatofugal signals to functionally different cortical areas.
References
Jan 1, 1992·Annual Review of Neuroscience·C R Gerfen
Mar 6, 1992·Brain Research·B Boda, M B Szente
Jul 1, 1990·Trends in Neurosciences·A M Graybiel
Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Mar 1, 1996·Neuroscience·M F MontaronA M Thierry
Mar 14, 1997·Brain Research·X D FanA V Juorio
Jan 1, 1997·Journal of Psychopharmacology·H J GroenewegenH B Uylings
Jun 17, 1998·Experimental Brain Research·S MaisonnetteR K Schwarting
Jul 23, 1999·Annals of the New York Academy of Sciences·H J GroenewegenP Voorn
Jul 28, 1999·Journal of Chemical Neuroanatomy·H J GroenewegenW J Smeets
Aug 3, 2001·Neuroscience·C DeransartA Depaulis
Oct 30, 2001·Neuroscience·R K FilipkowskiL Kaczmarek
Nov 13, 2001·The European Journal of Neuroscience·H Steiner, S T Kitai
Dec 6, 2001·European Journal of Pharmacology·M Gernert, W Löscher
Feb 27, 2003·The European Journal of Neuroscience·Fabio BlandiniGiuseppe Nappi
Feb 3, 2005·Journal of Neurochemistry·Anastasia SimiNiclas Tindberg
Sep 20, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·J FinnieP Blumbergs