Selective lesions of mesostriatal dopamine neurons ameliorate hypoglycemic damage in the caudate-putamen

Experimental Brain Research
O LindvallB K Siesjö

Abstract

Unilateral 6-hydroxydopamine lesion of the mesostriatal dopaminergic system was found to ameliorate neuronal necrosis in the caudate-putamen following 30 min of insulin-induced hypoglycemic coma. We propose that increased release of dopamine in the striatum during hypoglycemia or in the recovery period potentiates a deleterious neuronal hyperexcitation, probably induced by excessive release of glutamate or related compounds, thereby aggravating neuronal necrosis.

Citations

Jan 1, 1988·Annals of Biomedical Engineering·D B McCreeryL A Bullara
Oct 5, 1987·Neuroscience Letters·M Y GlobusP Scheinberg
Jan 1, 1993·Journal of Neurochemistry·A PastuszkoM Delivoria-Papadopoulos
Mar 1, 1988·Diabetes/metabolism Reviews·B K Siesjö
Jun 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L M Auer, N Ishiyama
Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·R N Auer
Oct 1, 1990·Stroke; a Journal of Cerebral Circulation·L K StruckJ K Dobson
Jul 23, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Andrew Nataraj, Ali H Rajput
Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·J K KraussF Mundinger
Jan 1, 1990·Movement Disorders : Official Journal of the Movement Disorder Society·K Hawker, A E Lang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.