Selective local PMN recruitment by CXCL1 or CXCL2/3 injection does not cause inflammatory pain

Journal of Leukocyte Biology
Heike L RittnerAlexander Brack

Abstract

Polymorphonuclear cells (PMN) are recruited in early inflammation and are believed to contribute to inflammatory pain. However, studies demonstrating a hyperalgesic role of PMN did not examine selective PMN recruitment or did not document effective PMN recruitment. We hypothesized that hyperalgesia does not develop after chemokine-induced PMN selective recruitment and is independent of PMN infiltration in complete Freund's adjuvant (CFA)-induced, local inflammation. PMN were recruited by intraplantar injection of CXC chemokine ligand 1 (CXCL1; keratinocyte-derived chemokine), CXCL2/3 (macrophage inflammatory protein-2), or CFA, with or without preceding systemic PMN depletion. Chemokine inoculation resulted in dose (0-30 microg)- and time (0-12 h)-dependent, selective recruitment of PMN as quantified by flow cytometry. CXCL2/3, but not CXCL1, was less effective at high doses, probably as a result of significant down-regulation of CXC chemokine receptor 2 expression on blood PMN. Neither chemokine caused mechanical or thermal hyperalgesia as determined by the Randall-Selitto and Hargreaves test, respectively, despite comparable expression of activation markers (i.e., CD11b, CD18, and L-selectin) on infiltrating PMN. In contrast,...Continue Reading

References

Nov 1, 1991·British Journal of Pharmacology·F Q CunhaS H Ferreira
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C SteinA Herz
Jul 1, 1989·Brain Research. Molecular Brain Research·G Draisci, M J Iadarola
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J D LevineE J Goetzl
Aug 7, 1993·Lancet·C SteinA Yassouridis
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·M SchaferC Stein
Jun 15, 1997·The Journal of Clinical Investigation·A BrackJ J Goronzy
Jan 20, 1998·Brain Research Bulletin·J A Harris
Apr 24, 1999·Journal of the American Society of Nephrology : JASN·S SuzukiF Gejyo
Sep 16, 1999·Experimental and Molecular Pathology·M T PiccoloG O Till
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T A MooreT J Standiford
Jul 6, 2000·Immunobiology·V GrauB Steiniger
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D YangJ J Oppenheim
Aug 22, 2000·The Journal of Investigative Dermatology·R M DevalarajaA Richmond
Jul 4, 2001·Nature Medicine·N VergnolleJ L Wallace
Aug 29, 2001·Anesthesia and Analgesia·A GuptaL Berggren
Sep 11, 2001·The American Journal of Pathology·D G RemickD R Call
Sep 15, 2001·Nature·D Julius, A I Basbaum
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M L BajtH Jaeschke
Jun 28, 2002·Immunological Reviews·B SteinigerV Grau
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Grant R StentonA Dean Befus
Sep 17, 2002·Biological & Pharmaceutical Bulletin·Futoshi ShibataHideo Nakagawa
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Otilia ObrejaMichaela Kress
Nov 2, 2002·Blood·Guo-Huang FanAnn Richmond
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patricia L PodolinHenry M Sarau

❮ Previous
Next ❯

Citations

Oct 15, 2013·Neuroscience Letters·John M Dawes, Stephen B McMahon
Jul 8, 2011·Science Translational Medicine·John M DawesStephen B McMahon
Dec 17, 2009·Medicine and Science in Sports and Exercise·Gøran PaulsenTruls Raastad
May 10, 2013·PloS One·Dagmar HackelHeike Lydia Rittner
Feb 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Niels EijkelkampAnnemieke Kavelaars
Jan 8, 2008·Current Rheumatology Reports·Heike L Rittner, Alexander Brack
Nov 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Nader GhasemlouClifford J Woolf
May 21, 2013·The Journal of Pain : Official Journal of the American Pain Society·Diana PflückeHeike L Rittner
Nov 3, 2009·Brain, Behavior, and Immunity·Melanie Busch-Dienstfertig, Christoph Stein
Jan 20, 2009·Brain Research Reviews·Christoph SteinRobert H Spencer
May 20, 2008·Brain Research Reviews·Carl Y SaabBryan C Hains
Apr 2, 2008·Neuroscience Letters·H L RittnerC Stein
Jul 21, 2007·Neuropeptides·Halina Machelska
Aug 2, 2013·European Journal of Pain : EJP·L ChenL Pei
May 23, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Preeti ViswanathanSanjeev Gupta
Aug 27, 2013·Osteoarthritis and Cartilage·M ThakurS B McMahon
Nov 25, 2016·Scientific Reports·Monoranjan BoroKithiganahalli Narayanaswamy Balaji
Mar 16, 2017·European Journal of Immunology·Rafael S CzepielewskiCristina Bonorino
Aug 16, 2015·Journal of Acupuncture and Meridian Studies·Raphael J HochstrasserSabine D Klein
Apr 22, 2018·British Journal of Pharmacology·Milad MohammadiHeike L Rittner
Jan 18, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anuradha RajamanickamSubash Babu
Jul 29, 2010·Journal of Periodontal Research·H J WrightP R Cooper
Oct 25, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Heike L RittnerAlexander Brack
Oct 3, 2017·Rheumatology·Ramin RaoofNiels Eijkelkamp
Feb 3, 2018·Pain Reports·Esther M Pogatzki-ZahnStephan A Schug
Oct 5, 2011·Pharmacological Reviews·Christoph Stein, Halina Machelska

❮ Previous
Next ❯

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