PMID: 7538720Jan 1, 1995Paper

Selective localization of gelatinase A, an enzyme degrading beta-amyloid protein, in white matter microglia and in Schwann cells

Acta Neuropathologica
T YamadaT Yamamoto

Abstract

Gelatinase A is an enzyme capable of cleaving soluble beta-amyloid protein (beta AP), and may function as an alpha-secretase to produce secretory forms of amyloid precursor protein. We examined gelatinase A immunoreactivity in the brains and posterior roots of neurologically normal, lacunar stroke, Alzheimer disease (AD), amyotrophic lateral sclerosis, progressive supranuclear palsy and myasthenia gravis cases. The gelatinase A antibody stained only microglial cells in the white matter in all the brain tissues. In AD brain, the reactive microglia located in the center of classical senile plaques, as well as in other microglial cells in the gray matter, showed no immunoreactivity. Gelatinase A in white matter microglial cells may play a role in preventing local deposition of beta AP. In the posterior root, Schwann cells had positive immunoreactivity. As with other metalloproteases, gelatinase A in Schwann cells may play an antiproliferative role.

References

Jan 1, 1992·The Journal of Cell Biology·D Muir, M Manthorpe
Jan 1, 1990·Acta Neuropathologica·L A MattiaceD W Dickson
Nov 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·H M WisniewskiB Lach
Feb 29, 1988·Biochemical and Biophysical Research Communications·S YamagataS Shimizu
Nov 1, 1985·Archives of Neurology·Z S Khachaturian

❮ Previous
Next ❯

Citations

Aug 21, 2009·The Journal of Biological Chemistry·Mei-Chen LiaoWilliam E Van Nostrand
Oct 19, 2006·Journal of Biomedicine & Biotechnology·Deng-Shun WangJames S Malter
Mar 28, 2008·Journal of Cellular and Molecular Medicine·D FarfaraD Frenkel
Apr 28, 2006·Nature Reviews. Immunology·Howard L Weiner, Dan Frenkel
Feb 15, 2012·Brain Pathology·Emma L BaileyJoanna M Wardlaw
Aug 12, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Fares BassilPierre-Olivier Fernagut
Oct 21, 2015·Frontiers in Pharmacology·Xiaojuan SunYan-Dong Wang
May 16, 2020·3 Biotech·Maruti J Dhanavade, Kailas D Sonawane
Oct 8, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Amal A Aziz, Zareen Amtul
May 15, 2002·Brain Research. Molecular Brain Research·E M MuirJ H Rogers
Feb 1, 1997·Journal of Neuroimmunology·S ChandlerA J Gearing
Jan 1, 1996·Advances in Neuroimmunology·J Zielasek, H P Hartung
Aug 23, 2005·Pharmacology & Therapeutics·Nobuhisa IwataTakaomi C Saido

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Related Papers

Journal of Clinical Neuromuscular Disease
L H Phillips
Journal of Neurology, Neurosurgery, and Psychiatry
S A MayerJ P Mohr
Journal of Pharmacological and Toxicological Methods
R G MorrisA Orfanos
© 2021 Meta ULC. All rights reserved