Abstract
Gelatinase A is an enzyme capable of cleaving soluble beta-amyloid protein (beta AP), and may function as an alpha-secretase to produce secretory forms of amyloid precursor protein. We examined gelatinase A immunoreactivity in the brains and posterior roots of neurologically normal, lacunar stroke, Alzheimer disease (AD), amyotrophic lateral sclerosis, progressive supranuclear palsy and myasthenia gravis cases. The gelatinase A antibody stained only microglial cells in the white matter in all the brain tissues. In AD brain, the reactive microglia located in the center of classical senile plaques, as well as in other microglial cells in the gray matter, showed no immunoreactivity. Gelatinase A in white matter microglial cells may play a role in preventing local deposition of beta AP. In the posterior root, Schwann cells had positive immunoreactivity. As with other metalloproteases, gelatinase A in Schwann cells may play an antiproliferative role.
References
Jan 1, 1992·Journal of Biochemistry·H YasumitsuM Umeda
Mar 1, 1992·Journal of Neuroscience Research·P L McGeerT Ishii
Jan 1, 1992·The Journal of Cell Biology·D Muir, M Manthorpe
Mar 1, 1992·Journal of Neurochemistry·J R BackstromZ A Tökés
Sep 30, 1991·Biochemical and Biophysical Research Communications·J R McDermott, A M Gibson
Feb 1, 1990·Neuron·T E GoldeS G Younkin
Jan 1, 1990·Acta Neuropathologica·L A MattiaceD W Dickson
Nov 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·H M WisniewskiB Lach
Feb 29, 1988·Biochemical and Biophysical Research Communications·S YamagataS Shimizu
Nov 1, 1985·Archives of Neurology·Z S Khachaturian
Feb 11, 1988·Nature·P PonteF Fuller
Jul 15, 1987·The Biochemical Journal·S ZuckerL M Golub
Jul 4, 1994·Neuroscience Letters·T TokudaN Yanagisawa
Feb 15, 1994·Journal of Neuroscience Research·V S SapirsteinN Marks
Feb 21, 1994·Brain Research·T YamadaE G McGeer
Jan 1, 1993·Acta Neuropathologica·H M Wisniewski, J Weigel
Apr 29, 1993·Nature·K MiyazakiM Umeda
Citations
Jan 7, 2010·Biochemistry·Mei-Chen Liao, William E Van Nostrand
Nov 8, 2002·Journal of Neurochemistry·A MiskoL Notterpek
Aug 21, 2009·The Journal of Biological Chemistry·Mei-Chen LiaoWilliam E Van Nostrand
Oct 19, 2006·Journal of Biomedicine & Biotechnology·Deng-Shun WangJames S Malter
Jul 20, 2002·Neuroscience·P M HughesK M Miller
Mar 28, 2008·Journal of Cellular and Molecular Medicine·D FarfaraD Frenkel
Jan 1, 1995·Acta Neuropathologica·T YamadaM Takahashi
Sep 5, 1997·The Journal of Biological Chemistry·T ItohS Itohara
Apr 28, 2006·Nature Reviews. Immunology·Howard L Weiner, Dan Frenkel
Feb 15, 2012·Brain Pathology·Emma L BaileyJoanna M Wardlaw
Aug 12, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Fares BassilPierre-Olivier Fernagut
Mar 5, 1998·Cancer·M H FriedbergG Perides
Aug 29, 2009·Journal of Neurotrauma·Armin KrausNektarios Sinis
Dec 13, 2017·Molecular Psychiatry·K E HoppertonR P Bazinet
Apr 29, 2015·Frontiers in Aging Neuroscience·Christian Humpel
Oct 21, 2015·Frontiers in Pharmacology·Xiaojuan SunYan-Dong Wang
May 16, 2020·3 Biotech·Maruti J Dhanavade, Kailas D Sonawane
Oct 8, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Amal A Aziz, Zareen Amtul
Jan 16, 1999·Journal of Neuroscience Research·S DebP E Gottschall
Aug 5, 2000·Molecular and Cellular Neurosciences·T A Ferguson, D Muir
May 15, 2002·Brain Research. Molecular Brain Research·E M MuirJ H Rogers
Feb 1, 1997·Journal of Neuroimmunology·S ChandlerA J Gearing
Jan 1, 1996·Advances in Neuroimmunology·J Zielasek, H P Hartung
Aug 23, 2005·Pharmacology & Therapeutics·Nobuhisa IwataTakaomi C Saido