Selective loss of pyramidal neurons in the pre-supplementary motor cortex in Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Virginia Macdonald, Glenda M Halliday

Abstract

The nonprimary motor cortices have not previously been studied in Parkinson's disease, despite the selective pattern of dysfunction observed in these regions. In particular, the pre-supplementary motor region is consistently underactive, with successful treatments correlating with increased excitatory drive to nonprimary motor regions. This finding could suggest a primary cortical abnormality in the pre-supplementary motor area (pre-SMA) in Parkinson's disease. We analysed and compared neuronal number in the pre-SMA and dorsolateral premotor cortical regions in 5 cases of Parkinson's disease and 5 controls. For each cortical region, the total neuronal number as well as the estimated numbers of subpopulations of interneurons and pyramidal neurons was quantified using previously published unbiased techniques. The results showed a significant loss of cortico-cortical projecting pyramidal neurons in the pre-SMA with no loss of other pyramidal neurons or interneurons either in this region or in the dorsolateral premotor region. These findings indicate a highly selective loss of pyramidal cells in the pre-SMA in Parkinson's disease, consistent with previous imaging findings in this disease. Our results implicate the degeneration of t...Continue Reading

References

Mar 1, 1997·Experimental Neurology·D A McRitchieG M Halliday
Aug 1, 1997·Neuroscience·J J KrilH Cartwright
Feb 14, 1998·Neuropathology and Applied Neurobiology·V MacdonaldE A McCusker
Jan 1, 1996·Journal of Neural Transmission·H BraakJ Bohl
Aug 26, 1998·Neuropathology and Applied Neurobiology·A J Harding, G M Halliday
Jan 29, 1999·Archives of Neurology·D J GelbS Gilman
Jun 17, 1999·Journal of Neural Transmission. Supplementum·D J Brooks
Dec 5, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·R MarcheseG Abbruzzese
Dec 29, 2000·Anatomy and Embryology·S GeyerK Zilles
Feb 13, 2001·Neurobiology of Disease·C E ShepherdG M Halliday
Feb 13, 2001·Trends in Neurosciences·F M Benes, N Lange
Feb 13, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·L S BoylanH A Sackeim
Feb 27, 2001·Brain : a Journal of Neurology·B HaslingerA O Ceballos-Baumann
Apr 12, 2001·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·A Y RazumovskyW A Baumgartner
Apr 12, 2001·Neuropathology and Applied Neurobiology·K A Sieradzan, D M Mann
Oct 18, 2001·Acta Neuropathologica·A J Harding, G M Halliday
Oct 24, 2001·Brain : a Journal of Neurology·A BerardelliM Hallett
Dec 13, 2001·Current Opinion in Neurobiology·N Picard, P L Strick
Dec 18, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·R CunningtonJ G Colebatch
Dec 18, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·P HaussermannA Ceballos-Baumann

❮ Previous
Next ❯

Citations

May 25, 2010·Nature Medicine·Jose A ObesoGlenda Halliday
Dec 20, 2008·Nature Reviews. Neuroscience·E Charles Leek, Stephen J Johnston
Sep 30, 2008·Cerebral Cortex·Lee J MartinMelissa A Landek
Nov 15, 2006·Current Opinion in Neurology·Parashkev Nachev
Sep 30, 2005·Dementia and Geriatric Cognitive Disorders·Katie WiltshireRichard Camicioli
Jun 22, 2014·Brain : a Journal of Neurology·Rafael González-RedondoMaría C Rodríguez-Oroz
May 6, 2014·Journal of Neural Transmission·Gabrielle ToddKay L Double
Oct 3, 2008·Neuropsychiatric Disease and Treatment·Adriana Vélez FeijóMárcia L F Chaves
Nov 4, 2015·Brain : a Journal of Neurology·Tao WuPiu Chan
Feb 10, 2016·Frontiers in Human Neuroscience·E Charles LeekStephen J Johnston
Feb 3, 2016·Frontiers in Neurology·Michael Schwartze, Sonja A Kotz
May 19, 2004·Acta Neurologica Scandinavica·X GuoG Steg
Aug 2, 2012·Neural Plasticity·Rinske VlamingsYasin Temel
May 18, 2016·Parkinson's Disease·Alexandru Hanganu, Oury Monchi
Oct 12, 2013·Neuroscience and Biobehavioral Reviews·David Lindenbach, Christopher Bishop
Dec 19, 2009·Neuropsychologia·James W MoorePatrick Haggard
Feb 15, 2015·Brain : a Journal of Neurology·Abraham MathaiYoland Smith
Feb 24, 2015·Frontiers in Neuroanatomy·Adriana GalvanThomas Wichmann
Feb 2, 2010·NeuroImage·G ToddK L Double
Jul 5, 2011·Neuroscience·T Wichmann, J O Dostrovsky
Feb 16, 2007·Brain Research Reviews·Patricia K AddamoNellie Georgiou-Karistianis
Jan 21, 2017·Nature Reviews. Neuroscience·D James SurmeierGlenda M Halliday
Jan 25, 2017·NeuroImage. Clinical·Lucas NürnbergerSimon Baudrexel
Jan 27, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Hatice KumruJosep Valls-Solé
Feb 27, 2018·Cell and Tissue Research·Jennifer A SteinerPatrik Brundin
Jul 24, 2004·The Journal of Physiology·Tarek SharsharMichael I Polkey
Sep 8, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Ann E KingsburyAndrew J Lees
Aug 29, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Etienne C HirschSerge Przedborski
Jan 12, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Richard M CamicioliW R Wayne Martin
Oct 10, 2008·Nature Reviews. Neuroscience·Parashkev NachevMasud Husain
Jul 15, 2005·Brain : a Journal of Neurology·Glenda M HallidayJasmine M Henderson
Jun 2, 2012·Expert Review of Neurotherapeutics·Glenda HallidayClaire Shepherd
Jan 5, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Florian LammersGeorg Winterer
Jun 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Glenda HallidayMatthew Stern
Jun 27, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Alexandru HanganuOury Monchi
Mar 29, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Richard CamicioliW R Wayne Martin
Sep 5, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Heather McCannGlenda M Halliday
Sep 25, 2019·Brain : a Journal of Neurology·Shuo WangUeli Rutishauser
Dec 8, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·J Eric Ahlskog
Sep 21, 2017·Experimental Brain Research·Thomas P WellingsRebecca Lim
Jan 11, 2020·Frontiers in Neurology·Jamie C BlairT Jason Druzgal
Sep 26, 2020·Frontiers in Molecular Neuroscience·Naila Kuhlmann, Austen J Milnerwood

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
Kamilla M PedersenBente Pakkenberg
Clinical and Experimental Pharmacology & Physiology
I Darian-SmithC Darian-Smith
© 2022 Meta ULC. All rights reserved