Selective loss of somatostatin receptor 2 in octreotide-resistant growth hormone-secreting adenomas

The Journal of Clinical Endocrinology and Metabolism
Ursula PlöckingerStefan Schulz

Abstract

The somatostatin analog octreotide preferentially binds to somatostatin receptor (sst) 2A and to a lesser extent to sst5. Although sst2A and sst5 mRNAs are consistently expressed in GH-secreting adenomas, octreotide controls GH secretion only in 65% of acromegalic patients. Hence, we investigated the immunocytochemical expression of sst in a large group of somatotroph tumors. Acromegalic patients, cared for in a university referral center, were either operated on without pretreatment (group A, n = 14) or pretreated with octreotide [median (minimum-maximum): dose 1250 (300-1500) mug/d for 5.6 (3-9) months] before surgery (group B, n = 20). In group B octreotide reduced GH secretion by more than 50% in 14 patients (70%) (GH responders). Six patients with less than 50% GH suppression were considered GH nonresponders. We used a panel of extensively characterized antibodies to determine the immunocytochemical sst status in somatotroph adenomas and compared their expression between the groups. All group A tumors demonstrated immunoreactive sst2A, and all but one had sst5. A similar pattern was found in the GH responders of group B. In contrast, none of the GH nonresponders exhibited detectable sst2A (sst2A: GH responders vs. GH nonre...Continue Reading

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Citations

Mar 7, 2009·Pituitary·A Soto MorenoA Leal Cerro
Jul 25, 2008·Reviews in Endocrine & Metabolic Disorders·Alexandru Saveanu, Philippe Jaquet
May 3, 2012·International Journal of Endocrinology·U Plöckinger
Dec 9, 2010·Diagnostic Pathology·Zhi-Gang MaoHai-Jun Wang
Aug 4, 2011·European Journal of Endocrinology·Darja CiganokaJanis Klovins
Nov 28, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Andrea Kliewer, Stefan Schulz
Jul 13, 2013·European Journal of Endocrinology·Bernhard MayrChristof Schöfl
Jul 11, 2014·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Baldomero GonzalezMoises Mercado
Mar 7, 2012·Expert Review of Clinical Pharmacology·Renato Cozzi, Roberto Attanasio
Dec 5, 2008·Expert Opinion on Investigational Drugs·Jens BollerslevJens P Berg
Jul 23, 2013·Frontiers in Neuroendocrinology·Marily Theodoropoulou, Günter K Stalla
Jan 7, 2016·Frontiers in Endocrinology·Erika PeverelliGiovanna Mantovani
Dec 7, 2013·British Journal of Pharmacology·Susann IllingStefan Schulz
Jul 16, 2010·Journal of Cellular and Molecular Medicine·Mehtap CakirAshley Grossman
Mar 11, 2011·Annals of the New York Academy of Sciences·Thomas CunyAlain Enjalbert
Jun 14, 2014·Pituitary·Cheng-Chia LeeJason Sheehan
Dec 31, 2014·International Journal of Endocrinology·Xu-Hui LiZhi Rong Qian
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Federico GattoLeo J Hofland
Oct 23, 2018·The Journal of Clinical Endocrinology and Metabolism·Ammar MuhammadSebastian J C M M Neggers
Aug 25, 2018·European Journal of Endocrinology·Monica MarazuelaMaria Chiara Zatelli
Mar 8, 2019·Journal of Cellular and Molecular Medicine·Eva Venegas-MorenoAlfonso Soto-Moreno
Dec 3, 2010·Endocrine Reviews·Annamaria ColaoRosario Pivonello
Apr 22, 2016·Molecular Endocrinology·Andreas LehmannStefan Schulz
Feb 19, 2011·Molecular Endocrinology·Falko NagelStefan Schulz
Feb 3, 2015·Clinical Endocrinology·Manuel Puig Domingo
Dec 22, 2017·Journal of Cellular and Molecular Medicine·Eva Venegas-MorenoAlfonso Soto-Moreno
Jul 9, 2010·Endocrinology·Stefan JacobsStefan Schulz
Feb 19, 2013·Molecular Endocrinology·Aline PetrichStefan Schulz

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