PMID: 6972764Jun 1, 1981Paper

Selective lymphocyte deficiency in seronegative rheumatoid arthritis

Arthritis and Rheumatism
J L PasqualiD A Carson

Abstract

Prior studies have shown that in vitro infection with the Epstein Barr virus (EBV) is able to induce IgM rheumatoid factor production by normal lymphocytes, with a higher degree of production by seropositive rheumatoid arthritis lymphocytes. The present investigation demonstrates that EBV-infected lymphocytes from patients with seronegative rheumatoid arthritis produce in vitro significantly less IgM rheumatoid factor than do normal lymphocytes. The results suggest that the peripheral blood of seronegative patients is deficient in the rheumatoid factor precursor B cells responsive to stimulation by Epstein Barr virus.

References

Jan 1, 1976·The Journal of Clinical Investigation·A N TheofilopoulosF J Dixon
Aug 1, 1977·The Journal of Experimental Medicine·D A Thorley-LawsonJ L Strominger
Jan 1, 1979·Scandinavian Journal of Immunology·A G Bird, S Britton
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M A CatalanoJ H Vaughan
Dec 1, 1966·Arthritis and Rheumatism·J C Allen, H G Kunkel
May 1, 1974·Arthritis and Rheumatism·N J Zvaifler
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G Miller, M Lipman
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen
Feb 1, 1980·Annals of the Rheumatic Diseases·D L Robbins, T L Moore

❮ Previous
Next ❯

Citations

Jan 1, 1984·Rheumatology International·G S AlarcónR E Schrohenloher
Jun 13, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y KasaharaF Chisari
Jan 1, 1984·Immunogenetics·E GomardJ P Lévy
Dec 30, 1983·The American Journal of Medicine·P Stastny
Apr 20, 2010·Arthritis Research & Therapy·Teresa A SimonUNKNOWN Abatacept Epidemiology Study Group
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·T L VischerR H Zubler
Dec 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·C Heilmann, J Petersen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.