Selective miscarriage of Down's syndrome fetuses in women aged 35 years and older

British Journal of Obstetrics and Gynaecology
M C MacintoshC Lundsteen

Abstract

To estimate the fetal loss of Down's syndrome fetuses between the time of chorionic villus sampling (10 weeks gestation) and the time of amniocentesis (16 weeks gestation) and term in women aged 35 years and older. The age specific prevalence rates in the first trimester of Down's syndrome were estimated using the Danish cytogenetic register in combination with results from four published studies. These were compared with the reported prevalence at the time of amniocentesis and at birth. 5927 singleton pregnancies undergoing chorionic villus sampling (71 cases of Down's syndrome and 5856 unaffected cases). This was combined with published data on a further 231 cases of Down's syndrome and 16,620 unaffected cases. Age specific prevalences at the time of chorionic villus sampling. Proportion of pregnancies lost between the time of chorionic villus sampling and the time of amniocentesis and term. Thirty-two percent of Down's syndrome pregnancies are lost between the time of chorionic villus sampling (10 weeks) and the time of amniocentesis (16 weeks) and 54% are lost by term. The high fetal loss rates of Down's syndrome between the time of chorionic villus sampling and term introduce problems when evaluating first trimester screen...Continue Reading

Citations

Oct 16, 1999·Prenatal Diagnosis·M ChristiansenB Norgaard-Pedersen
Dec 30, 1996·Early Human Development·B W MolJ van der Meulen
Jan 8, 1999·BMJ : British Medical Journal·B W Mol
Aug 25, 2001·BMJ : British Medical Journal·R E GilbertJ H van Der Meulen
Mar 26, 2004·American Journal of Obstetrics and Gynecology·Joseph R BiggioJeffery S A Stringer
May 12, 2016·Revista da Associação Médica Brasileira·Vanessa Vigna GoulartMarcelo Zugaib
Dec 21, 1996·Lancet·A K HackshawJ E Haddow
Jul 30, 1999·British Journal of Obstetrics and Gynaecology·J H van der MeulenW Voorn
Dec 1, 1995·Prenatal Diagnosis·N J WaldA K Hackshaw
Apr 2, 1998·The New England Journal of Medicine·J E HaddowA Johnson
May 23, 2000·Prenatal Diagnosis·P A Benn, J F Egan
Apr 25, 2006·Prenatal Diagnosis·George M SavvaEva Alberman
May 1, 1996·British Journal of Obstetrics and Gynaecology·N M FiskL Abramsky
May 15, 2010·Expert Review of Molecular Diagnostics·M P H Wendy KosterPeter C J I Schielen
Jun 19, 1998·American Journal of Medical Genetics·C P Torfs, R E Christianson
Jun 3, 1998·British Journal of Obstetrics and Gynaecology·M MacintoshJ Seth
Nov 1, 1996·British Journal of Obstetrics and Gynaecology·M C MacintoshC Lundsteen
Jan 1, 1997·Journal of Medical Screening·N J WaldA McGuire
Jul 1, 1998·British Journal of Obstetrics and Gynaecology·J C DornanC A Bailie
Feb 19, 2016·Prenatal Diagnosis·Teresa N SparksAaron B Caughey
Oct 17, 2003·Journal of Medical Screening·A M SummersP R Wyatt
Oct 1, 1996·British Journal of Obstetrics and Gynaecology·B W MolC M Bilardo
Feb 17, 1998·Annals of Clinical Biochemistry·F D Dunstan, A B Nix
Oct 21, 2020·Prenatal Diagnosis·Howard Cuckle, Joan Morris

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