Jul 3, 2008

Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia

The American Journal of Psychiatry
Anantha ShekharChristian C Felder

Abstract

There are significant unmet needs in the treatment of schizophrenia, especially for the treatment of cognitive impairment, negative syndrome, and cognitive function. Preclinical data suggest that agonists with selective affinity for acetylcholine muscarinic receptors provide a potentially new mechanism to treat schizophrenia. The authors studied xanomeline, a relatively selective muscarinic type 1 and type 4 (M(1) and M(4)) receptor agonist, to determine if this agent is effective in the treatment of schizophrenia. In this pilot study, the authors examined the efficacy of xanomeline on clinical outcomes in subjects with schizophrenia (N=20) utilizing a double-blind, placebo-controlled, 4-week treatment design. Outcome measures included the Positive and Negative Syndrome Scale (PANSS) for schizophrenia, the Brief Psychiatric Rating Scale (BPRS), the Clinical Global Impression (CGI) scale, and a test battery designed to measure cognitive function in patients with schizophrenia. Subjects treated with xanomeline did significantly better than subjects in the placebo group on total BPRS scores and total PANSS scores. In the cognitive test battery, subjects in the xanomeline group showed improvements most robustly in measures of verba...Continue Reading

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Mentioned in this Paper

Pyridines
Schizophrenia
Memory for Designs Test
Xanomeline
Severity of Illness Index
Xanomeline tartrate
Cholinergic Receptors
Mild Cognitive Disorder
Agonist
Brief Psychiatric Rating Scale

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