Selective Neuromodulation of the Vagus Nerve.

Frontiers in Neuroscience
Adam FitchettKirill Aristovich

Abstract

Vagus nerve stimulation (VNS) is an effective technique for the treatment of refractory epilepsy and shows potential for the treatment of a range of other serious conditions. However, until now stimulation has generally been supramaximal and non-selective, resulting in a range of side effects. Selective VNS (sVNS) aims to mitigate this by targeting specific fiber types within the nerve to produce functionally specific effects. In recent years, several key paradigms of sVNS have been developed-spatially selective, fiber-selective, anodal block, neural titration, and kilohertz electrical stimulation block-as well as various stimulation pulse parameters and electrode array geometries. sVNS can significantly reduce the severity of side effects, and in some cases increase efficacy of the treatment. While most studies have focused on fiber-selective sVNS, spatially selective sVNS has demonstrated comparable mitigation of side-effects. It has the potential to achieve greater specificity and provide crucial information about vagal nerve physiology. Anodal block achieves strong side-effect mitigation too, but is much less specific than fiber- and spatially selective paradigms. The major hurdle to achieving better selectivity of VNS is a...Continue Reading

References

Mar 1, 1993·Journal of Biomedical Engineering·J RozmanB Zorko
Nov 16, 2001·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·E Ben-Menachem
Jul 10, 2003·Lancet Neurology·Elinor Ben-Menachem
Jun 12, 2004·Medical & Biological Engineering & Computing·K L Kilgore, N Bhadra
Nov 1, 2005·Medical & Biological Engineering & Computing·K HenningsO K Andersen
Apr 29, 2006·Journal of Applied Physiology·Leszek KubinDonald R McCrimmon
Jun 2, 2009·Medical Hypotheses·Hong Li, Tian-De Yang
Oct 30, 2010·European Heart Journal·Gaetano M De FerrariUNKNOWN CardioFit Multicenter Trial Investigators
Feb 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gergely VidaLuis Ulloa
Sep 17, 2011·Science·Mauricio Rosas-BallinaKevin J Tracey
May 4, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Thomas J HoffmannCharles W Emala
Jul 25, 2012·Surgical Neurology International·Scott E Krahl
Sep 4, 2012·Handbook of Clinical Neurology·Aidan NeliganJosemir W Sander
Sep 19, 2012·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Simone C M A OrdelmanPeter H Veltink
Dec 12, 2012·Surgical Neurology International·Scott E Krahl, Kevin B Clark
Oct 11, 2013·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Dennis T T PlachtaThomas Stieglitz
Apr 1, 2014·TheScientificWorldJournal·Polona Pečlin, Janez Rozman
May 9, 2014·Journal of Neural Engineering·Dennis T T PlachtaJoseph Zentner
Aug 15, 2014·Frontiers in Human Neuroscience·Parveen N S BawaRichard B Stein
Sep 28, 2014·Lancet·Solomon L MoshéTorbjörn Tomson
Apr 15, 2015·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Kurt Y QingPedro P Irazoqui
May 16, 2015·European Heart Journal·John S Floras, Piotr Ponikowski
Sep 16, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Jeffrey L ArdellJ Andrew Armour
Nov 20, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mortimer Gierthmuehlen, Dennis T T Plachta
Jan 10, 2016·Journal of Cardiovascular Translational Research·Rahul AgarwalCraig M Stolen
Jan 15, 2016·PloS One·Mortimer GierthmuehlenDennis T T Plachta
Mar 24, 2016·Journal of Neural Engineering·Henry T LancashireGordon W Blunn
Apr 9, 2016·Journal of the American College of Cardiology·Michael R GoldDouglas L Mann
May 26, 2016·Advances in Therapy·Dennis T T PlachtaMortimer Gierthmuehlen
Sep 16, 2016·Nature Reviews. Disease Primers·Christian OtteAlan F Schatzberg
Feb 9, 2018·Journal of Neural Engineering·Yogi A Patel, Robert J Butera
Feb 27, 2018·Bioelectronics in Medicine·Robin M McAllenJohn B Furness

❮ Previous
Next ❯

Software Mentioned

BaroLoop
COMSOL
VNS
sVNS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.