PMID: 7543251Jul 1, 1995Paper

Selective neuronal nitric oxide synthase inhibition blocks furosemide-stimulated renin secretion in vivo

The American Journal of Physiology
W H Beierwaltes

Abstract

The macula densa is a regulatory site for renin. It contains exclusively the neuronal isoform of nitric oxide synthase (NOS), suggesting NO could stimulate renin secretion through the macula densa pathway. To test whether neuronal NOS mediates renin secretion, renin was stimulated by either the renal baroreceptor or the diuretic furosemide (acting through the macula densa pathway). Renin secretion rate (RSR) was measured in 12 Inactin-anesthetized rats at normal (104 +/- 3 mmHg) and reduced renal perfusion pressure (65 +/- 1 mmHg), before and after selective blockade of the neuronal NOS with 7-nitroindazole (7-NI, 50 mg/kg ip). 7-NI had no effect on basal blood pressure (102 +/- 2 mmHg) or renal blood flow (RBF). Decreasing renal perfusion pressure doubled RSR from 11.8 +/- 3.3 to 22.9 +/- 5.7 ng ANG I.h-1.min-1 (P < 0.01) (ANG I is angiotensin I). Similarly, in 7-NI-treated rats, reduced perfusion doubled RSR from 8.5 +/- 1.8 to 20.5 +/- 6.2 ng ANG I.h-1.min-1 (P < 0.01). Renal hemodynamics and RSR were measured in response to 5 mg/kg iv furosemide in 12 control rats and 11 rats treated with 7-NI. Blocking neuronal NOS did not alter blood pressure (102 +/- 2 mmHg), RBF (5.8 +/- 0.4 ml.min-1.g kidney wt-1), or renal vascular re...Continue Reading

Citations

Mar 16, 2001·American Journal of Physiology. Renal Physiology·W WeichertS Bachmann
Jun 13, 2002·American Journal of Physiology. Renal Physiology·William H Beierwaltes
Jun 18, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David L Mattson, Carla J Meister
Jul 28, 2010·The Journal of Physiology·Fernando MonteroBernardo Moreno-López
Aug 13, 2011·American Journal of Physiology. Renal Physiology·Carie S FacemireThomas M Coffman
May 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·A CharbonneauM G Brunette
Nov 30, 2000·American Journal of Physiology. Renal Physiology·L XuR W Schrier
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jennifer C SullivanJennifer S Pollock
Jul 28, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Douglas K AtchisonWilliam H Beierwaltes
Aug 17, 2012·American Journal of Physiology. Renal Physiology·Douglas K AtchisonWilliam H Beierwaltes
Dec 12, 2001·American Journal of Physiology. Renal Physiology·William H BeierwaltesEdward G Shesely
Jan 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·R L RairighS H Abman
Sep 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C M Sayago, W H Beierwaltes
Feb 2, 2006·American Journal of Physiology. Renal Physiology·William H Beierwaltes
Jul 15, 2000·American Journal of Physiology. Renal Physiology·H F ChengR C Harris
Mar 11, 2004·American Journal of Physiology. Renal Physiology·Alex PaliegeTianxin Yang
Apr 13, 2004·American Journal of Physiology. Renal Physiology·Hayo CastropJurgen Schnermann
Aug 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Helmy M SiragyRobert M Carey
Jun 6, 2012·Pflügers Archiv : European journal of physiology·Jurgen Schnermann, Josephine P Briggs
Jun 16, 2001·American Journal of Physiology. Renal Physiology·R C Harris, M D Breyer
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M KakokiD L Mattson
Oct 7, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Liliya M YamaleyevaMark C Chappell
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Feb 1, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elzbieta Kompanowska-JezierskaPeter Bie
Jun 24, 2004·American Journal of Physiology. Renal Physiology·Scott C ThomsonFrancis B Gabbai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Renal Physiology
W H Beierwaltes
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
C M Sayago, W H Beierwaltes
American Journal of Physiology. Renal Physiology
W H BeierwaltesEdward G Shesely
© 2021 Meta ULC. All rights reserved