Selective neurotoxic damage to the hippocampal formation impairs performance of the transverse patterning and location memory tasks in rhesus macaques

Hippocampus
Maria C Alvarado, Jocelyne Bachevalier

Abstract

Monkeys with neurotoxic (ibotenic acid) damage to the hippocampal formation and unoperated controls were trained on two sets of transverse patterning problems (A+/B-, B+/C-, C+/A-, and D+/E-, E+/F-, F+/D-) and a delayed nonmatching-to-location paradigm (DNML) with delays of 10s, 30s, 120s, and 600s. Hippocampal lesions produced a size- and area-dependent impairment on transverse patterning. Damage largely limited to the right hippocampus in one subject had no effect on performance on the task. Of the remaining four subjects, two with hippocampal damage greater than 40% bilaterally were unable to solve the two transverse patterning sets, but could solve the linear set of discriminations (A+/B-, B+/C-, C+/X-). The two remaining operated animals were impaired in acquisition of both sets, but were eventually able to solve one of the two transverse patterning discrimination sets. All five operated monkeys were impaired relative to normal controls on DNML, but not on the standard delayed nonmatching-to-sample (DNMS) version with trial-unique objects. The results confirm our previous findings (Alvarado et al., Hippocampus 12:421-433, 2002) using aspiration lesions of the hippocampal formation and strengthen the view that the hippocamp...Continue Reading

References

Feb 1, 1986·Behavioural Brain Research·J P AggletonJ N Rawlins
Nov 1, 1984·Journal of Neuroscience Methods·W Hodos, P Bobko
Aug 15, 1998·Journal of Neurophysiology·M ColomboC G Gross
Aug 26, 1998·Journal of Cognitive Neuroscience·T C Rickard, J Grafman
Jan 9, 1999·Hippocampus·M B Moser, E I Moser
Jul 27, 2000·Annals of the New York Academy of Sciences·E A MurrayL M Saksida
Jul 27, 2000·Annals of the New York Academy of Sciences·W A Suzuki, H Eichenbaum
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·L Rondi-ReigS Tonegawa
Sep 4, 2001·Hippocampus·L MálkováR C Saunders
Nov 24, 2001·Behavioural Brain Research·H Eichenbaum
Feb 19, 2002·The European Journal of Neuroscience·Timothy J BusseyElisabeth A Murray
Dec 7, 2002·Journal of Neuroscience Methods·Sarah NemanicJocelyne Bachevalier
Apr 12, 2003·Brain : a Journal of Neurology·P J BrastedS P Wise
Oct 17, 2003·Neuroreport·Faith M HanlonJose M Cañive
Nov 15, 2003·Cerebral Cortex·Ira DriscollRobert J Sutherland
Feb 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah NemanicJocelyne Bachevalier
Apr 22, 2004·Hippocampus·Alison R PrestonJohn D E Gabrieli
Apr 22, 2004·Hippocampus·Stephan HeckersDebra Titone
Feb 1, 1947·The Journal of Comparative Neurology·J K PEDEN, G VON BONIN
Apr 1, 1947·Journal of Neuropathology and Experimental Neurology·J P MURPHY, R ARANA

❮ Previous
Next ❯

Citations

Jul 20, 2007·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Martin Giurfa
May 12, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jue HeXin-Min Li
Apr 27, 2010·Schizophrenia Bulletin·Laura M RowlandHenry H Holcomb
Apr 10, 2007·Annual Review of Neuroscience·Elisabeth A MurrayLisa M Saksida
Apr 30, 2008·Applied Neuropsychology·Noelle E Carlozzi, David G Thomas
Apr 28, 2012·Neuroscience and Biobehavioral Reviews·Francesco P BattagliaRens Bod
Aug 17, 2005·The European Journal of Neuroscience·Livia de HozRichard G M Morris
Jun 15, 2007·The European Journal of Neuroscience·Christopher J Machado, Jocelyne Bachevalier
Oct 1, 2010·Hippocampus·Maria C AlvaradoJocelyne Bachevalier
Apr 16, 2005·Current Opinion in Neurobiology·Jocelyne Bachevalier, Faraneh Vargha-Khadem
Apr 7, 2016·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Maria C D'AngeloJennifer D Ryan
Dec 3, 2014·Behavioural Brain Research·Masafumi NejimeShigehiro Miyachi
Jul 19, 2011·NeuroImage·Faith M HanlonClaudia D Tesche
Mar 14, 2009·NeuroImage·Sandra N MosesAnthony Randal McIntosh
Nov 12, 2016·Developmental Cognitive Neuroscience·Maria C AlvaradoJocelyne Bachevalier
Nov 19, 2013·Behavioral Sciences·Elena A SpiekerLaura M Rowland
May 18, 2006·Reviews in the Neurosciences·Masao YukieTetsumori Yamashima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.