Selective photobiomodulation for emotion regulation: model-based dosimetry study

Neurophotonics
Paolo CassanoQianqian Fang

Abstract

The transcranial photobiomodulation (t-PBM) technique is a promising approach for the treatment of a wide range of neuropsychiatric disorders, including disorders characterized by poor regulation of emotion such as major depressive disorder (MDD). We examine various approaches to deliver red and near-infrared light to the dorsolateral prefrontal cortex (dlPFC) and ventromedial prefrontal cortex (vmPFC) in the human brain, both of which have shown strong relevance to the treatment of MDD. We apply our hardware-accelerated Monte Carlo simulations to systematically investigate the light penetration profiles using a standard adult brain atlas. To better deliver light to these regions-of-interest, we study, in particular, intranasal and transcranial illumination approaches. We find that transcranial illumination at the F3-F4 location (based on 10-20 system) provides excellent light delivery to the dlPFC, while a light source located in close proximity to the cribriform plate is well-suited for reaching the vmPFC, despite the fact that accessing the latter location may require a minimally invasive approach. Alternative noninvasive illumination strategies for reaching vmPFC are also studied and both transcranial illumination at the Fp...Continue Reading

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Citations

Jul 25, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Reza Meynaghizadeh-ZargarSaeed Sadigh-Eteghad
Sep 25, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Farzad SalehpourPaolo Cassano
Jun 6, 2019·Lasers in Medical Science·Ranieli Cavalcante Dos SantosMayron F Oliveira
May 6, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Farzad SalehpourJoseph O DiDuro
Feb 25, 2021·Lasers in Medical Science·Fatemeh RamezaniMichael R Hamblin
Mar 31, 2021·Scientific Reports·Siyuan PangIwona Jasiuk
Mar 19, 2021·Journal of Biophotonics·Alexander P DumontChetan A Patil
May 4, 2021·Journal of Alzheimer's Disease : JAD·Farzad SalehpourMichael R Hamblin
Dec 24, 2021·Photobiomodulation, Photomedicine, and Laser Surgery·Tolga Atilla CeranogluGagan Joshi
Dec 31, 2021·Voprosy kurortologii, fizioterapii, i lechebnoĭ fizicheskoĭ kultury·A N BelovaA M Rezenova

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