Selective photosensitizer localization in the human endometrium after intrauterine application of 5-aminolevulinic acid

American Journal of Obstetrics and Gynecology
M K FehrY Tadir

Abstract

Our purpose was twofold: to determine the distribution of the endogenous photosensitizer protoporphyrin IX in the uterus and to ascertain the time interval leading to maximal endometrial fluorescence after intrauterine instillation of 5-aminolevulinic acid. One milliliter of a 400 mg/ml 5-aminolevulinic acid-Hyskon solution was instilled into the uterine cavity of 27 women before hysterectomy. On frozen sections of uterine samples 5-aminolevulinic acid-induced fluorescence was measured with fluorescence microscopy. 5-Aminolevulinic acid-induced fluorescence could first be detected in the superficial endometrial glands 75 minutes after drug injection. In the endometrial gland stumps fluorescence intensity peaked 4 to 8 hours after 5-aminolevulinic acid instillation and was > 48 times higher than in the underlying myometrium. Fluorescence in the endometrial glands suggests that selective photodynamic destruction of the endometrium may be possible 4 to 8 hours after intrauterine 5-aminolevulinic acid instillation.

References

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Citations

Apr 8, 1998·BMJ : British Medical Journal·S G Bown
Sep 13, 2008·Photomedicine and Laser Surgery·M Wolun-CholewaE Nowak-Markwitz
Apr 17, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·P WyssU Haller
Feb 22, 2011·Photodiagnosis and Photodynamic Therapy·Maria Wołuń-CholewaWojciech Warchoł
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Oct 2, 2002·Lasers in Surgery and Medicine·Kristin A KeefeBradley J Monk
Mar 7, 2000·Journal of the Royal Society of Medicine·D C ShackleyJ V Moore

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