PMID: 7030279Aug 1, 1981Paper

Selective plasma component removal: alternatives to plasma exchange

Artificial Organs
A A Pineda, H F Taswell

Abstract

Plasma exchange, the unselective removal of all plasma constituents, has been applied, with varying degrees of success, to an increasing number of disorders. Because of the high cost of plasma exchange, largely the result of expensive homologous replacement solution, and other reasons, alternatives have been sought. Selective removal of plasma components permits the use of autologous plasma as replacement which is less costly, more physiologic, and in some cases, a more efficient alternative to plasma exchange. The selective removal of plasma components whose presence is associated with a disease process can be accomplished presently by physical or chemical means with either on-line of off-line systems. A state-of-the-art review of currently available alternatives to plasma exchange is described. This includes hemoperfusion and plasmaperfusion over affinity columns or filters with immobilized sorbents. On-line separation of macromolecules by membrane filtration and cryoprecipitation as well as off-line chemical precipitation and cryoprecipitation are also described. The potential and limitations of the techniques are emphasized.

References

Jul 1, 1978·Archives of Disease in Childhood·C M Drillien
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Jan 1, 1976·Annals of the New York Academy of Sciences·E M HershR G Vincent
Jan 1, 1977·Scandinavian Journal of Immunology·D S TermanR McIntosh
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Jul 1, 1980·The Biochemical Journal·K M GautvikT B Orstavik
Aug 1, 1980·Artificial Organs·P S MalcheskyY Nosé

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Citations

Feb 1, 1997·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·H E Kambic, Y Nosé
Jan 1, 1984·Annales Françaises D'anesthèsie Et De Rèanimation·P Charbonneau
Mar 23, 2000·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Y NoséJ W Smith

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