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Selective pressures at a codon-level predict deleterious mutations in human disease genes

Journal of Molecular Biology

May 19, 2006

Leonardo ArbizaHernán Dopazo

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Abstract

Deleterious mutations affecting biological function of proteins are constantly being rejected by purifying selection from the gene pool. The non-synonymous/synonymous substitution rate ratio (omega) is a measure of selective pressure on amino acid replacement mutations for protein-codin...read more

Mentioned in this Paper

White catfish allergenic extract
Amino Acid [EPC]
Immunologic Deficiency Syndromes
Amino Acid Substitution
Online Mendelian Inheritance In Man
Helix (Snails)
Siluriformes
Mutant
Tupaia glis
Anatomy, Regional
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Selective pressures at a codon-level predict deleterious mutations in human disease genes

Journal of Molecular Biology

May 19, 2006

Leonardo ArbizaHernán Dopazo

PMID: 16584746

DOI: 10.1016/j.jmb.2006.02.067

Abstract

Deleterious mutations affecting biological function of proteins are constantly being rejected by purifying selection from the gene pool. The non-synonymous/synonymous substitution rate ratio (omega) is a measure of selective pressure on amino acid replacement mutations for protein-codin...read more

Mentioned in this Paper

White catfish allergenic extract
Amino Acid [EPC]
Immunologic Deficiency Syndromes
Amino Acid Substitution
Online Mendelian Inheritance In Man

Similar Papers Found In These Feeds

Paper Details
References
  • References33
  • Citations25
1234
  • References33
  • Citations25
123

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