Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell.

Investigational New Drugs
Tanveer SharifGuy Fuhrmann

Abstract

Cancer stem cells are expected to be responsible for tumor initiation and metastasis. These cells are therefore potential targets for innovative anticancer therapies. However, the absence of bona fide cancer stem cell lines is a real problem for the development of such approaches. Since teratocarcinoma cells are totipotent stem cells with a high degree of malignancy, we used them as a model of cancer stem cells in order to evaluate the anticancer chemopreventive activity of red wine polyphenols (RWPs) and to determine the underlying cellular and molecular mechanisms. We therefore investigated the effects of RWPs on the embryonal carcinoma (EC) cell line P19 which was grown in the same culture conditions as the most appropriate normal cell line counterpart, the pluripotent embryonic fibroblast cell line NIH/3T3. The present study indicates that RWPs selectively inhibited the proliferation of P19 EC cells and induced G1 cell cycle arrest in a dose-dependent manner. Moreover, RWPs treatment specifically triggered apoptosis of P19 EC cells in association with a dramatic upregulation of the tumor suppressor gene p53 and caspase-3 activation. Our findings suggest that the chemopreventive activity of RWPs on tumor initiation and devel...Continue Reading

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Citations

Aug 13, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I TedescoG L Russo
May 28, 2016·International Journal of Environmental Research and Public Health·Yue ZhouHua-Bin Li
Dec 9, 2016·Autophagy·Tanveer SharifShashi A Gujar
Dec 17, 2016·Cell Biology and Toxicology·Fathi EmhemmedGuy Fuhrmann
Jan 12, 2013·Food & Function·Fang LiXiang-Rong Xu
Aug 31, 2019·Journal of the Chinese Medical Association : JCMA·Kai-Feng HungShou-Yen Kao
Jul 21, 2015·Critical Reviews in Food Science and Nutrition·Jairam Vanamala
Apr 28, 2019·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Fathi EmhemmedGuy Fuhrmann

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