Selective protection against extremes in childhood body size, abdominal fat deposition, and fat patterning in breastfed children

Archives of Pediatrics & Adolescent Medicine
T CrumeD Dabelea

Abstract

To determine whether the effect of breastfeeding on childhood measures of adiposity differs across percentiles of childhood body mass index (BMI), subcutaneous (SAT) and visceral (VAT) adipose tissue deposition, ratio of subcutaneous to triceps skinfold (STR), and intramyocellular lipid accumulation (IMCL). Retrospective cohort. Denver, Colorado. Four hundred forty-two children and adolescents aged 6 to 13 years participating in the Exploring Perinatal Outcomes Among Children study (EPOCH) with material recall of infant diet. Adequate (≥6 breast milk-months) vs low (<6 breast milk-months) neonatal breastfeeding status. Mean and percentile differences in BMI, SAT, VAT, STR, and IMCL between children who had adequate compared with low levels of breastfeeding. No significant differences in mean levels of childhood adiposity levels between adequate and low breastfeeding status were detected using linear regression models. However, in quantile regression models, adequate breastfeeding was associated with lower levels of adiposity levels for those in the upper percentiles (>60th percentile for VAT, 85th and 95th percentiles for BMI, and 95th percentiles for SAT and STR) and a null effect for those at the 50th percentile or lower. The...Continue Reading

Citations

Nov 9, 2012·Current Diabetes Reports·Melanie Cree-GreenKristen J Nadeau
Apr 5, 2013·Pediatric Obesity·B G Gibbs, R Forste
May 23, 2012·Nature Reviews. Endocrinology·Caroline Barranco

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