Selective quasispecies transmission after systemic or mucosal exposure of macaques to simian immunodeficiency virus

Virology
O NeildezD Dormont

Abstract

Sexual transmission is the major cause of the AIDS epidemic. For the development of new antiviral and vaccine strategies, we therefore need to understand the mechanisms by which lentiviruses cross the mucosal barrier and the subsequent pathogenic consequences. For this purpose, experimental approaches are greatly facilitated by the development of relevant animal models. In this study, macaques were inoculated intravenously, intrarectally, or intravaginally with a pathogenic cell-free isolate of SIVmac251. Patterns of virological and immunological events significantly differed between vaginally (transient viremia, late seroconversion) and intravenously or intrarectally inoculated monkeys (persistent viremia and early seroconversion). Two weeks after infection, analysis of the env gene nucleotide sequences of proviruses recovered from PBMCs demonstrated that most of the differences were observed in the V1 loop. Three viral variants were specifically associated with vaginal transmission, whereas no such selection was evidenced after intravenous or intrarectal transmissions. These results are in favor of specific mechanisms associated with vaginal transmission, implicating viral envelope structure.

References

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Citations

Jan 15, 2002·AIDS Research and Human Retroviruses·M J BurkhardE A Hoover
Feb 13, 2002·AIDS Research and Human Retroviruses·Mary Jo BurkhardEdward A Hoover
Mar 9, 2002·Journal of Virology·Deborah Heydenburg FullerMichael Murphey-Corb
Jan 16, 2007·Annual Review of Medicine·Andrew A Lackner, Ronald S Veazey
Aug 10, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·C Tévi-BenissanL Bélec
Apr 15, 1999·AIDS·P L VernazzaM S Cohen
Jan 26, 2005·AIDS·Donald P Kotler
Apr 19, 2003·La Revue de médecine interne·D Dormont
May 23, 2009·Gastroenterology·Andrew A LacknerRonald S Veazey

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