Abstract
Sexual transmission is the major cause of the AIDS epidemic. For the development of new antiviral and vaccine strategies, we therefore need to understand the mechanisms by which lentiviruses cross the mucosal barrier and the subsequent pathogenic consequences. For this purpose, experimental approaches are greatly facilitated by the development of relevant animal models. In this study, macaques were inoculated intravenously, intrarectally, or intravaginally with a pathogenic cell-free isolate of SIVmac251. Patterns of virological and immunological events significantly differed between vaginally (transient viremia, late seroconversion) and intravenously or intrarectally inoculated monkeys (persistent viremia and early seroconversion). Two weeks after infection, analysis of the env gene nucleotide sequences of proviruses recovered from PBMCs demonstrated that most of the differences were observed in the V1 loop. Three viral variants were specifically associated with vaginal transmission, whereas no such selection was evidenced after intravenous or intrarectal transmissions. These results are in favor of specific mechanisms associated with vaginal transmission, implicating viral envelope structure.
References
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L Spouge
Dec 1, 1992·Virology·N AlmondP Kitchin
Oct 1, 1992·Journal of Virology·J Overbaugh, L M Rudensey
Aug 1, 1991·PCR Methods and Applications·K Hayashi
Dec 1, 1991·Journal of Virology·J OverbaughW R Morton
Oct 24, 1991·Nature·T LehnerM Chapman
Jan 1, 1990·Annual Review of Immunology·R C Desrosiers
Oct 19, 1989·Nature·V M HirschJ I Mullins
Jun 7, 1985·Science·M D DanielR C Desrosiers
May 20, 1983·Science·F Barré-SinoussiL Montagnier
Mar 1, 1995·AIDS·R Le GrandA M Aubertin
Oct 1, 1994·AIDS Research and Human Retroviruses·R Le GrandD Dormont
Nov 1, 1994·Journal of Virology·P TrivediC D Pauza
Nov 11, 1994·Nucleic Acids Research·J D ThompsonT J Gibson
Oct 1, 1994·Journal of Virology·C J MillerA G Hendrickx
Aug 1, 1993·AIDS Research and Human Retroviruses·N A HynesV M Hirsch
Aug 27, 1993·Science·T ZhuD D Ho
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G ScarlattiM Uhlén
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J FantiniF Gonzalez-Scarano
Jun 1, 1993·Journal of Virology·L Q ZhangP Simmonds
Jan 1, 1996·The Journal of Experimental Medicine·A I SpiraD D Ho
Mar 1, 1996·Science·L E Soto-RamirezM Essex
Jan 1, 1996·Glia·G GuilleminD Dormont
Sep 1, 1996·AIDS Research and Human Retroviruses·A ChéretD Dormont
Jan 1, 1997·Nature Medicine·M Bomsel
Citations
Feb 23, 2012·The Journal of Biological Chemistry·Joanna S OlsenStephen Dewhurst
Jan 15, 2002·AIDS Research and Human Retroviruses·M J BurkhardE A Hoover
Feb 13, 2002·AIDS Research and Human Retroviruses·Mary Jo BurkhardEdward A Hoover
Feb 27, 1999·Human Gene Therapy·F MatheuxE Lauret
Jun 9, 2009·AIDS Research and Human Retroviruses·Aaron B ReeveFrancis J Novembre
Nov 3, 2006·Journal of Virology·Pushpa JayaramanNancy L Haigwood
Oct 3, 2001·Journal of Virology·J S HallD C Stenger
Mar 27, 2001·Journal of Virology·J L GreenierM L Marthas
Mar 9, 2002·Journal of Virology·Deborah Heydenburg FullerMichael Murphey-Corb
Jan 16, 2007·Annual Review of Medicine·Andrew A Lackner, Ronald S Veazey
Apr 2, 2009·Immunogenetics·Edward T MeeNicola J Rose
Aug 10, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·C Tévi-BenissanL Bélec
Jan 12, 2007·Immunogenetics·Anne AverdamLutz Walter
Apr 15, 1999·AIDS·P L VernazzaM S Cohen
Jan 26, 2005·AIDS·Donald P Kotler
Feb 26, 2009·AIDS·Olivier BourryRoger Le Grand
Apr 21, 2010·Tissue Antigens·E T MeeN J Rose
Jan 30, 2007·Virology·Lily TsaiCecilia Cheng-Mayer
Jun 19, 2007·Virology·Silvana TascaCecilia Cheng-Mayer
May 30, 2006·Virology·Nataliya TrunovaCecilia Cheng-Mayer
Dec 3, 2003·Virology·Anne Couëdel-CourteilleCécile Butor
Feb 9, 2016·AIDS·Céline CamusNathalie Dejucq-Rainsford
Sep 15, 2017·Journal of Virology·Ulrike SauermannChristiane Stahl-Hennig
Apr 10, 1999·Journal of Virology·D L SodoraR I Connor
Aug 8, 1998·Journal of Virology·P J ValliJ Goudsmit
Mar 12, 1999·Journal of Virology·P PolacinoS L Hu
Apr 19, 2003·La Revue de médecine interne·D Dormont
May 23, 2009·Gastroenterology·Andrew A LacknerRonald S Veazey
Aug 24, 1999·Science·C Stahl-HennigP Racz