Selective recruitment maneuvers for lobar atelectasis: effects on lung function and central hemodynamics: an experimental study in pigs

Anesthesia and Analgesia
Lars Kjaersgaard HansenA Larsson

Abstract

We investigated whether selective lung recruitment of a lobar collapse would improve oxygenation and lung volume as well as a general (global) lung recruitment maneuver, with fewer circulatory side effects. In 10 ventilated, anesthetized pigs, a bronchial blocker was inserted in the right lower lobe, which was selectively lavaged to create a dense lobar collapse. The pigs were randomized into two orders of lung recruitment maneuvers (40 cm H2O airway pressure for 30 s): either a selective lung recruitment maneuver (using the inner lumen of the bronchial blocker) followed by a general lung recruitment maneuver, or vice versa. Median end-expiratory lung volume and median Pao2 increased significantly by approximately 100 mL and 16 kPa, respectively, with no significant differences between the two recruitment methods. There were no circulatory changes during the selective lung recruitment maneuver, but during the general lung recruitment maneuver, mean arterial blood pressure decreased significantly by 36 (21, 41) mm Hg (median, 25th and 75th percentiles), cardiac output by 2.1 (1.6, 2.5) L/min and left ventricular end-diastolic area by 4.4 (3.5, 4.5) cm2. In conclusion, a selective recruitment maneuver improved lung function simil...Continue Reading

References

May 1, 1992·The Annals of Thoracic Surgery·Y J GuC R Wildevuur
Nov 1, 1992·Acta Anaesthesiologica Scandinavica·T HachenbergM Wendt
Oct 1, 1990·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·E J RicciardelliA F Inglis
Jun 1, 1980·Acta Anaesthesiologica Scandinavica·B LachmannJ Vogel
Dec 1, 1993·British Journal of Anaesthesia·H U RothenG Hedenstierna
Sep 3, 1999·British Journal of Anaesthesia·H U RothenG Hedenstierna
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Jeffrey M HalterGary F Nieman
May 20, 2003·Clinical Physiology and Functional Imaging·Göran Hedenstierna
Apr 24, 2004·Anesthesia and Analgesia·Silvia NunesStephan M Jakob
Dec 18, 2004·Intensive Care Medicine·Helena OdenstedtStefan Lundin
Apr 19, 2005·The Lancet Infectious Diseases·Joanna Lumb
Aug 13, 2005·Intensive Care Medicine·Jonas NielsenAnders Larsson

❮ Previous
Next ❯

Citations

Mar 17, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Ignacio GaruttiFrancisco de la Gala
Dec 20, 2008·Acta Anaesthesiologica Scandinavica·C K MarumoJ O C Auler
Dec 19, 2015·BioMed Research International·András Lovas, Tamás Szakmány
Apr 1, 2014·Paediatric Respiratory Reviews·Jacqui Jauncey-CookeFiona Bogossian
Jul 19, 2008·Seminars in Cardiothoracic and Vascular Anesthesia·Francis Theodore Lytle, Daniel R Brown
Dec 21, 2006·Anesthesia and Analgesia·Jens Lohser
Jun 6, 2019·Transplantation Direct·Toshihiro OkamotoKenneth R McCurry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.