Selective redox-responsive drug release in tumor cells mediated by chitosan based glycolipid-like nanocarrier

Journal of Controlled Release : Official Journal of the Controlled Release Society
Ying-wen HuFu-qiang Hu

Abstract

The redox responsive nanocarriers have made a considerable progress in achieving triggered drug release by responding to the endogenous occurring difference between the extra- and intra- cellular redox environments. Despite the promises, this redox difference exists both in normal and tumor tissue. So a non-selective redox responsive drug delivery system may result in an undesired drug release in normal cells and relevant side-effects. To overcome these limitations, we have developed a chitosan based glycolipid-like nanocarrier (CSO-ss-SA) which selectively responded to the reducing environment in tumor cells. The CSO-ss-SA showed an improved reduction-sensitivity which only fast degraded and released drug in 10mM levels of glutathione (GSH). The CSO-ss-SA could transport the drug fast into the human ovarian cancer SKOV-3 cells and human normal liver L-02 cells by internalization, but only fast release drug in SKOV-3 cells. By regulating the intracellular GSH concentration in SKOV-3 cells, it indicated that the cellular inhibition of the PTX-loaded CSO-ss-SA showed a positive correlation with the GSH concentration. The CSO-ss-SA was mainly located in the liver, spleen and tumor in vivo, which evidenced the passive tumor targeti...Continue Reading

References

Mar 1, 1985·The Journal of Cell Biology·P GreenspanS D Fowler
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Mar 17, 2000·Free Radical Biology & Medicine·D P JonesP Sternberg
Jan 14, 2003·Annual Review of Biochemistry·Hiroshi KadokuraJon Beckwith
Jul 25, 2003·Chemical Communications : Chem Comm·Elizabeth R Gillies, Jean M J Fréchet
Jul 14, 2005·Annual Review of Nutrition·Archana Jaiswal McEligotFrank L Meyskens
Mar 7, 2006·Journal of the American College of Cardiology·Salman AshfaqArshed A Quyyumi
May 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Salvador MenaJosé M Estrela
Apr 10, 2008·Journal of the American Chemical Society·Seiji TakaeKazunori Kataoka
Jul 29, 2009·Antioxidants & Redox Signaling·Merridee A WoutersNaomi L Haworth
Dec 19, 2009·Antioxidants & Redox Signaling·Luksana Chaiswing, Terry D Oberley
Oct 23, 2010·Journal of Internal Medicine·D P Jones
Feb 8, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ru ChengZhiyuan Zhong
Jun 20, 2012·Annual Review of Analytical Chemistry·Robin L McCarley
Aug 8, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Lin Zhu, Vladimir P Torchilin
Nov 6, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Daniele PezzoliGabriele Candiani
Nov 7, 2012·Angewandte Chemie·Lorine BrülisauerJean-Christophe Leroux
Jun 7, 2013·Advanced Materials·Jinqiang WangZhongwei Gu
Sep 26, 2013·Advanced Drug Delivery Reviews·Yuanpei LiKit S Lam
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Nov 26, 2013·Advanced Drug Delivery Reviews·Nicolas BertrandOmid C Farokhzad
Dec 18, 2013·Antioxidants & Redox Signaling·Shivanjali Joshi-BarrAdah Almutairi
May 7, 2014·Antioxidants & Redox Signaling·Marc A Gauthier
Jun 22, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lorine BrülisauerJean-Christophe Leroux
Dec 6, 2014·Advanced Functional Materials·Yucai WangYounan Xia

❮ Previous
Next ❯

Citations

Sep 1, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kathleen A RossBalaji Narasimhan
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Na AnFengyu Qu
Nov 5, 2016·Colloids and Surfaces. B, Biointerfaces·Xingzhen ZhangGuangxi Zhai
Oct 6, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sung Eun KimKyeongsoon Park
Jul 6, 2018·Chemical Communications : Chem Comm·Qian ChengRuibing Wang
Jan 1, 2019·Journal of Drug Targeting·Leila AlizadehMohammad Rahmati-Yamchi
Jan 18, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Wei-Liang YeSi-Yuan Zhou
Feb 13, 2018·BioImpacts : BI·Marziyeh FathiYadollah Omidi
Sep 7, 2017·Current Medicinal Chemistry·Yan ShengLy James Lee
Dec 25, 2019·IUBMB Life·Maryam ChamaniZatollah Asemi
Jul 9, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Parinaz SabourianAshok Kakkar
Jun 27, 2020·Journal of Biomaterials Science. Polymer Edition·Lijuan WangJiang Yuan
Sep 25, 2020·Expert Opinion on Drug Delivery·Joydeb Majumder, Tamara Minko
May 12, 2016·Journal of Biomaterials Applications·Fang WangChaobo Huang
Mar 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cheng GaoRuibing Wang
Nov 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jun LiXiao-Qi Yu
May 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yue SunPeihong Ni
Jun 18, 2019·Anti-cancer Agents in Medicinal Chemistry·Denisa Ficai, Anton Ficai
Sep 24, 2018·Journal of Nanobiotechnology·Xiaoshuang GuoWei-En Yuan
Dec 28, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marion BruneauSylvain Pluchon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.